Rosenbaum Christoph, Gerds Naemi, Hack Liliane, Weitschies Werner
Department of Biopharmaceutics and Pharmaceutical Technology, Institute of Pharmacy, University of Greifswald, Felix-Hausdorff-Straße 3, 17489 Greifswald, Germany.
Pharmaceutics. 2024 Aug 22;16(8):1103. doi: 10.3390/pharmaceutics16081103.
Fiber-based technologies are widely used in various industries, but their use in pharmaceuticals remains limited. While melt extrusion is a standard method for producing medical fibers such as sutures, it is rarely used for pharmaceutical fiber-based dosage forms. The EsoCap system is a notable exception, using a melt-extruded water-soluble filament as the drug release trigger mechanism. The challenge of producing drug-loaded fibers, particularly due to the use of spinning oils, and the processing of the fibers are addressed in this work using other approaches. The aim of this study was to develop processes for the production and processing of pharmaceutical fibers for targeted drug delivery. Fibers loaded with polyvinyl alcohol and fluorescein sodium as a model drug were successfully prepared by a continuous melt extrusion process and directly spun. These fibers exhibited uniform surface smoothness and consistent tensile strength. In addition, the fibers were further processed into tubular dosage forms using a modified knitting machine and demonstrated rapid drug release in a flow cell.
基于纤维的技术在各个行业中广泛应用，但在制药领域的应用仍然有限。虽然熔融挤出是生产诸如缝合线等医用纤维的标准方法，但很少用于基于药物纤维的剂型。EsoCap系统是一个显著的例外，它使用熔融挤出的水溶性长丝作为药物释放触发机制。本文采用其他方法解决了生产载药纤维的挑战，特别是由于纺丝油的使用以及纤维的加工问题。本研究的目的是开发用于靶向药物递送的药用纤维的生产和加工工艺。通过连续熔融挤出工艺成功制备了负载聚乙烯醇和荧光素钠作为模型药物的纤维，并直接纺丝。这些纤维表现出均匀的表面光滑度和一致的拉伸强度。此外，使用改进的针织机将纤维进一步加工成管状剂型，并在流通池中显示出快速的药物释放。
