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Viable adhered Staphylococcus aureus highly reduced on novel antimicrobial sutures using chlorhexidine and octenidine to avoid surgical site infection (SSI).使用洗必泰和奥替尼啶的新型抗菌缝线可使存活的黏附金黄色葡萄球菌大量减少，从而避免手术部位感染（SSI）。
PLoS One. 2018 Jan 9;13(1):e0190912. doi: 10.1371/journal.pone.0190912. eCollection 2018.
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Suture materials - Current and emerging trends.缝合材料——当前趋势与新进展
J Biomed Mater Res A. 2016 Jun;104(6):1544-59. doi: 10.1002/jbm.a.35683. Epub 2016 Apr 4.
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Combining in the melt physical and biological properties of poly(caprolactone) and chlorhexidine to obtain antimicrobial surgical monofilaments.将聚己内酯的熔融物理和生物特性与洗必泰相结合，以获得抗菌手术单丝。
Appl Microbiol Biotechnol. 2013 Jan;97(1):99-109. doi: 10.1007/s00253-012-4283-x. Epub 2012 Jul 21.
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Prophylaxis versus placebo treatment for infective and inflammatory complications of surgical third molar removal: a split-mouth, double-blind, controlled, clinical trial with amoxicillin (500 mg).预防性使用阿莫西林（500毫克）与安慰剂治疗外科拔除第三磨牙的感染性和炎性并发症：一项采用阿莫西林的双盲、对照、分口临床试验
J Oral Maxillofac Surg. 2011 Nov;69(11):e333-9. doi: 10.1016/j.joms.2011.03.055. Epub 2011 Jul 29.
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Routine antibiotic prophylaxis is not necessary during operations to remove third molars.拔除第三磨牙的手术过程中无需常规预防性使用抗生素。
Br J Oral Maxillofac Surg. 2008 Mar;46(2):133-5. doi: 10.1016/j.bjoms.2006.11.005. Epub 2006 Dec 22.
6
Postoperative prophylactic antibiotic treatment in third molar surgery--a necessity?第三磨牙手术中的术后预防性抗生素治疗——有必要吗？
J Oral Maxillofac Surg. 2004 Jan;62(1):3-8; discussion 9. doi: 10.1016/j.joms.2003.05.004.
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Prophylactic antibiotics for third molar surgery: a dissenting opinion.智齿拔除术预防性使用抗生素：一种不同意见。
J Oral Maxillofac Surg. 1995 Jan;53(1):61-4. doi: 10.1016/0278-2391(95)90503-0.
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An assessment of the use of prophylactic antibiotics in third molar surgery.
Int J Oral Surg. 1974;3(1):1-6. doi: 10.1016/s0300-9785(74)80030-x.
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Chlorhexidine diacetate and povidone-iodine cytotoxicity to canine embryonic fibroblasts and Staphylococcus aureus.醋酸氯己定和聚维酮碘对犬胚胎成纤维细胞和金黄色葡萄球菌的细胞毒性。
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下颌阻生第三磨牙拔除术后口服预防性抗生素与单纯放置抗菌缝线预防手术部位感染效果的比较研究

Comparative Study on the Efficacy of Postsurgical Oral Prophylactic Antibiotic Versus Antimicrobial Suture Placement Alone in Preventing Surgical Site Infection After Removal of Impacted Mandibular Third Molar.

作者信息

Mohan Shama, Jayanth B S, Saralaya Shruthi, Sunil S M, Sageer A S Mohamed, Harikrishnan R

机构信息

Department of Oral and Maxillofacial Surgery, Coorg Institute of Dental Sciences, Virajpet, Karnataka India.

出版信息

J Maxillofac Oral Surg. 2020 Dec;19(4):546-551. doi: 10.1007/s12663-019-01267-0. Epub 2019 Aug 2.

DOI:10.1007/s12663-019-01267-0
PMID:33071503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7524983/
Abstract

AIM

To evaluate the efficacy of postsurgical oral prophylactic antibiotic versus antimicrobial suture placement in preventing infection after removal of an impacted mandibular third molar.

MATERIALS AND METHODS

This was a prospective, single-blind study including 150 individuals of 18-40 years divided into two groups with 75 patients each. The patients in Group 1 were administered oral amoxicillin tablets 500 mg for 5 days postsurgery with 3-0 polyglactin sutures for closure and in group 2 with (3-0) antimicrobial chlorhexidine diacetate-impregnated polyglactin sutures only. Evaluation was done on 3rd, 7th, 15th days and 1 month.

RESULTS

There was no significant difference in rates of infection between the groups. Abnormal erythema, pain and trismus showed statistically better results in group 2 on 3rd and 7th days. An antibiotic side effect assessment showed 17.65% patients with minor side effects.

CONCLUSION

Chlorhexidine diacetate-impregnated polyglactin sutures showed reduced erythema, pain and trismus in healthy patients undergoing surgical removal of third molar.

摘要

目的

评估术后口服预防性抗生素与放置抗菌缝线在预防下颌阻生第三磨牙拔除术后感染中的疗效。

材料与方法

这是一项前瞻性单盲研究，纳入150名年龄在18至40岁的个体，分为两组，每组75例患者。第1组患者术后口服500毫克阿莫西林片，持续5天，并用3-0聚乙醇酸缝线缝合；第2组仅使用（3-0）含抗菌剂醋酸氯己定的聚乙醇酸缝线。在第3天、第7天、第15天和1个月进行评估。

结果

两组之间的感染率无显著差异。在第3天和第7天，第2组的异常红斑、疼痛和牙关紧闭在统计学上显示出更好的结果。抗生素副作用评估显示，17.65%的患者有轻微副作用。

结论

对于接受第三磨牙手术拔除的健康患者，含醋酸氯己定的聚乙醇酸缝线可减少红斑、疼痛和牙关紧闭。