Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Sci Rep. 2024 Mar 1;14(1):5134. doi: 10.1038/s41598-024-55747-6.
A two-arm randomized open labeled controlled clinical trial was conducted on 50 patients with non-alcoholic fatty liver disease (NAFLD). Subjects were randomized to either receive two tablets of soy isoflavone (100 mg/day) or placebo. At week 12, the serum levels of alanine amino transferase (ALT), aspartate amino transferase (AST) and controlled attenuation parameter (CAP) score were significantly decreased only in the soy isoflavone group (P < 0.05). A significant decline in the gamma glutamyl transferase (GGT) level was observed only in the placebo group (P = 0.017). A significant increase in the serum level of fetuin A was shown in both groups at the end of the trial with a significantly greater increment in the soy isoflavone group compared to the placebo group (P < 0.05). The changes in the serum level of FGF-21 were not significant in any of the two groups. Steatosis grade significantly improved only in the soy isoflavone group (P = 0.045). There was no significant change in the fibrosis grade in the groups. Soy isoflavone intake led to a decrease in ALT, AST, CAP score, steatosis grade and an increase in the level of fetuin A. However, no significant changes were observed in the fibrosis grade and serum levels of GGT and FGF-21.
一项针对 50 例非酒精性脂肪性肝病（NAFLD）患者的双盲随机对照临床试验。将受试者随机分为两组，分别给予 2 片大豆异黄酮（100mg/天）或安慰剂。在第 12 周时，仅在大豆异黄酮组血清丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）和受控衰减参数（CAP）评分显著降低（P<0.05）。仅在安慰剂组γ谷氨酰转移酶（GGT）水平显著下降（P=0.017）。试验结束时，两组血清胎球蛋白 A 水平均显著升高，大豆异黄酮组与安慰剂组相比，胎球蛋白 A 水平显著升高（P<0.05）。两组血清成纤维细胞生长因子 21（FGF-21）水平变化均不显著。仅在大豆异黄酮组肝脂肪变性程度显著改善（P=0.045）。两组纤维化程度均无明显变化。大豆异黄酮摄入可降低 ALT、AST、CAP 评分、肝脂肪变性程度，并升高胎球蛋白 A 水平。然而，纤维化程度和血清 GGT 和 FGF-21 水平无明显变化。
