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Alterations of iron homeostasis as a potential druggable driver of long COVID.

作者信息

Marques Oriana, Muckenthaler Martina U

机构信息

Department of Pediatric Oncology, Hematology and Immunology and Hopp Children Cancer Center (KiTZ), University Hospital Heidelberg, Heidelberg, Germany.

Molecular Medicine Partnership Unit (MMPU), EMBL and University of Heidelberg, Heidelberg, Germany.

出版信息

Nat Immunol. 2024 Mar;25(3):387-389. doi: 10.1038/s41590-024-01759-3.

DOI:10.1038/s41590-024-01759-3
PMID:38429459
Abstract
摘要

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本文引用的文献

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Mechanisms controlling cellular and systemic iron homeostasis.控制细胞和全身铁稳态的机制。
Nat Rev Mol Cell Biol. 2024 Feb;25(2):133-155. doi: 10.1038/s41580-023-00648-1. Epub 2023 Oct 2.
2
Impaired iron recycling from erythrocytes is an early hallmark of aging.红细胞中铁的循环利用受损是衰老的早期标志。
Elife. 2023 Jan 31;12:e79196. doi: 10.7554/eLife.79196.
3
Long COVID: major findings, mechanisms and recommendations.长新冠：主要发现、机制和建议。
Trends Endocrinol Metab. 2024 Dec;35(12):1026-1049. doi: 10.1016/j.tem.2024.04.015. Epub 2024 May 17.
Nat Rev Microbiol. 2023 Mar;21(3):133-146. doi: 10.1038/s41579-022-00846-2. Epub 2023 Jan 13.
4
Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial.英国心力衰竭伴缺铁患者的静脉注射铁右旋糖酐（IRONMAN）：一项由研究者发起的、前瞻性、随机、开放标签、盲终点试验。
Lancet. 2022 Dec 17;400(10369):2199-2209. doi: 10.1016/S0140-6736(22)02083-9. Epub 2022 Nov 5.
5
The role of iron in chronic inflammatory diseases: from mechanisms to treatment options in anemia of inflammation.铁在慢性炎症性疾病中的作用：从机制到炎症性贫血的治疗选择。
Blood. 2022 Nov 10;140(19):2011-2023. doi: 10.1182/blood.2021013472.
6
Thalassaemia is paradoxically associated with a reduced risk of in-hospital complications and mortality in COVID-19: Data from an international registry.地中海贫血症与 COVID-19 住院并发症和死亡率降低呈矛盾相关：来自国际登记处的数据。
J Cell Mol Med. 2022 May;26(9):2520-2528. doi: 10.1111/jcmm.17026. Epub 2022 Mar 30.
7
Iron metabolism in infections: Focus on COVID-19.感染中的铁代谢：聚焦 COVID-19。
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Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection.亚铁调素介导的低铁血症破坏了对疫苗接种和感染的免疫反应。
Med. 2021 Feb 12;2(2):164-179.e12. doi: 10.1016/j.medj.2020.10.004.
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