Department of Rehabilitation Medicine,The Affiliated Taian City Central Hospital of Qingdao University, Taian 271000, China.
Department of Skills Training Center,The Affiliated Taian City Central Hospital of Qingdao University, Taian 271000, China.
Biomed Pharmacother. 2024 Apr;173:116350. doi: 10.1016/j.biopha.2024.116350. Epub 2024 Mar 1.
Diabetic peripheral neuropathy (DPN) is one of the most prevalent consequences of diabetes, with a high incidence and disability rate. The DPN's pathogenesis is extremely complex and yet to be fully understood. Persistent high glucose metabolism, nerve growth factor deficiency, microvascular disease, oxidative stress, peripheral nerve cell apoptosis, immune factors, and other factors have been implicated in the pathogenesis of DPN. Astragalus mongholicus is a commonly used plant used to treat DPN in clinical settings. Its rich chemical components mainly include Astragalus polysaccharide, Astragalus saponins, Astragalus flavones, etc., which play a vital role in the treatment of DPN. This review aimed to summarize the pathogenesis of DPN and the studies on the mechanism of the effective components of Astragalus mongholicus in treating DPN. This is of great significance for the effective use of Chinese herbal medicine and the promotion of its status and influence on the world.
糖尿病周围神经病变（DPN）是糖尿病最常见的后果之一，具有较高的发病率和致残率。DPN 的发病机制极其复杂，尚未完全阐明。持续的高葡萄糖代谢、神经生长因子缺乏、微血管疾病、氧化应激、周围神经细胞凋亡、免疫因素等都与 DPN 的发病机制有关。蒙古黄芪是临床治疗 DPN 的常用植物。其丰富的化学成分主要包括黄芪多糖、黄芪皂苷、黄芪黄酮等，在治疗 DPN 中发挥着重要作用。本综述旨在总结 DPN 的发病机制及蒙古黄芪有效成分治疗 DPN 的作用机制的研究进展，这对于中药的有效利用以及提高其在世界上的地位和影响力具有重要意义。
