Department of Mechanical Engineering, National Cheng Kung University (NCKU), Tainan 70101, Taiwan.
Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan; The iEGG and Animal Biotechnology Center, Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan.
Int J Biol Macromol. 2024 Apr;264(Pt 1):130547. doi: 10.1016/j.ijbiomac.2024.130547. Epub 2024 Feb 29.
Plasticizers like Bis(2-ethylhexyl)phthalate (DEHP) are commonly used to enhance plastic properties but pose environmental and health risks. This study successfully derived plasticizers X and Y from rice straws, demonstrating efficacy in chitosan polymer coatings. Chitosan-based polymers exhibit exceptional hardness, with a value of 300 MPa, due to their enriched structure and robust chitosan bonding. This surpasses the hardness of DEHP. Zebrafish exposure over 5 days revealed that X and Y had no significant behavioral impact, while DEHP caused noticeable toxic effects. Maternal DEHP exposure reduced placental cell growth, unlike X and Y, which had no adverse effects on uterine differentiation or placenta formation, suggesting their safety in human pregnancy. The successful development of X and Y represents a crucial step towards greener plasticizers, addressing environmental concerns and promoting safer alternatives in various industries.
增塑剂如邻苯二甲酸二（2-乙基己基）酯（DEHP）通常用于增强塑料性能，但存在环境和健康风险。本研究成功地从稻草中提取出增塑剂 X 和 Y，并证明了它们在壳聚糖聚合物涂层中的功效。基于壳聚糖的聚合物由于其丰富的结构和坚固的壳聚糖键合，表现出异常的硬度，达到 300 MPa，超过了 DEHP 的硬度。斑马鱼暴露在 DEHP 中超过 5 天，没有发现 X 和 Y 对其行为有明显的影响，而 DEHP 则会引起明显的毒性作用。与 X 和 Y 不同，母体 DEHP 的暴露会降低胎盘细胞的生长，这表明它们在人类妊娠期间是安全的，不会对子宫分化或胎盘形成产生不良影响。X 和 Y 的成功开发是朝着更环保的增塑剂迈出的关键一步，解决了环境问题，并在各个行业中促进了更安全的替代品的发展。
