铜及其配合物在心血管疾病中的作用。
Role of copper and its complexes in cardiovascular diseases.
作者信息
Zhu Wenjun, Zhang Yiyue, Luo Xiuju, Peng Jun
机构信息
Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078.
Department of Laboratory Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023 Nov 28;48(11):1731-1738. doi: 10.11817/j.issn.1672-7347.2023.230159.
Copper is a trace element essential for the maintenance of normal physiological functions in cardiovascular system, and its transport and metabolisms are regulated by various copper proteins such as copper-based enzymes, copper chaperones and copper transporters. The disturbance of copper level or abnormal expression of copper proteins are closely associated with the development of cardiovascular diseases such as atherosclerosis, hypertension, ischemic heart disease, myocardial hypertrophy and heart failure. Thus, intervention of copper ion signaling pathways is expected to be an effective measure for treating cardiovascular diseases. Some copper complexes, such as trientine, copper-aspirinate complex and copper (II) diethyldithiocarbamate, have been found to play a role in the prevention and treatment of cardiovascular diseases and possess potential prospects. Exploring the role of copper in maintaining normal cardiovascular status and the potential application of copper complexes in the treatment of cardiovascular diseases may lay a foundation for finding new targets for prevention and treatment of various cardiovascular diseases, and provide new ideas for clinical treatment of cardiovascular diseases.
铜是维持心血管系统正常生理功能所必需的微量元素，其运输和代谢受多种铜蛋白调控，如铜基酶、铜伴侣蛋白和铜转运体。铜水平的紊乱或铜蛋白的异常表达与动脉粥样硬化、高血压、缺血性心脏病、心肌肥大和心力衰竭等心血管疾病的发生密切相关。因此，干预铜离子信号通路有望成为治疗心血管疾病的有效措施。一些铜配合物，如曲恩汀、阿司匹林铜配合物和二乙基二硫代氨基甲酸铜（II），已被发现对心血管疾病的防治具有作用，并具有潜在前景。探索铜在维持心血管正常状态中的作用以及铜配合物在心血管疾病治疗中的潜在应用，可能为寻找各种心血管疾病防治的新靶点奠定基础，并为心血管疾病的临床治疗提供新思路。
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