Shida Ryutaro, Iwakura Takamasa, Ohashi Naro, Ema Chiemi, Aoki Taro, Tashiro Takeshi, Ishigaki Sayaka, Isobe Shinsuke, Fujikura Tomoyuki, Kato Akihiko, Nakamura Tomohiko, Fujigaki Yoshihide, Shimizu Akira, Yasuda Hideo
First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan.
Blood Purification Unit, Hamamatsu University School of Medicine, Japan.
Intern Med. 2024;63(5):699-705. doi: 10.2169/internalmedicine.2126-23.
A 50-year-old man diagnosed with anti-contactin 1 (CNTN1) antibody-associated chronic inflammatory demyelinating polyneuropathy (CIDP) was referred to our department for the evaluation of proteinuria. A kidney biopsy revealed membranous nephropathy (MN). Immunohistochemistry for CNTN1 revealed positive granular staining along the glomerular basement membrane, confirming anti-CNTN1 antibody-associated MN. Immunofluorescence showed a full-house pattern, and several autoantibodies, such as anti-nuclear antibody, anti-double-strand DNA antibody, and anti-cardiolipin antibody, were detected in the patient's serum. Although limited autoantibodies have been investigated in some of the reported cases, a variety of autoantibodies might be produced in anti-CNTN1 antibody-associated CIDP, accompanied by MN.
一名50岁男性被诊断为抗接触蛋白1（CNTN1）抗体相关的慢性炎症性脱髓鞘性多发性神经病（CIDP），因蛋白尿问题转诊至我科。肾脏活检显示为膜性肾病（MN）。CNTN1免疫组化显示沿肾小球基底膜呈阳性颗粒状染色，证实为抗CNTN1抗体相关的MN。免疫荧光显示满堂亮模式，且在患者血清中检测到多种自身抗体，如抗核抗体、抗双链DNA抗体和抗心磷脂抗体。尽管在一些已报道病例中仅研究了有限的自身抗体，但抗CNTN1抗体相关的CIDP伴MN可能会产生多种自身抗体。
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