Bayraktar Eltutan Ceyda, Rinaldi Simon, Vural Atay, Aksu Bagdagul, Maras Genc Hülya, Pembegul Yildiz Edibe
Division of Pediatric Neurology, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Front Immunol. 2025 Jun 18;16:1549363. doi: 10.3389/fimmu.2025.1549363. eCollection 2025.
We present a 12-year-old boy with acute onset sensorimotor neuropathy and membranous glomerulonephritis associated with contactin-1 antibodies. This prompted us to explore the clinical characteristics of this condition and assess whether its presentation differs between pediatric and adult patients. A comprehensive search was conducted across multiple online databases, including PubMed and EMBASE, using MeSH terms such as "chronic inflammatory demyelinating polyradiculopathy", "acute inflammatory demyelinating polyradiculopathy ", "CIDP", "Guillain Barre syndrome", "proteinuria", "nephrotic syndrome", "nephropathy", "renal disease", "glomerulonephritis", "membranous nephropathy", "autoimmune nodopathies", and "membranous glomerulonephritis". We reviewed publications up to October 2024 and identified 39 patients with anti-contactin associated CIDP (chronic inflammatory demyelinating polyradiculopathy) with membranous glomerulonephritis (MGN), including our case. This rare coexistence typically occurs at advanced ages, with only two pediatric cases. Clinical features were similar regardless of age at onset. We compared the onset, symptoms, progression, renal histopathology, and treatment responses between pediatric and adult patients.
我们报告了一名12岁男孩，患有急性起病的感觉运动性神经病和与接触蛋白-1抗体相关的膜性肾小球肾炎。这促使我们探究这种疾病的临床特征，并评估其在儿科和成人患者中的表现是否存在差异。我们使用“慢性炎症性脱髓鞘性多发性神经根神经病”“急性炎症性脱髓鞘性多发性神经根神经病”“慢性炎症性脱髓鞘性多发性神经根神经病（CIDP）”“吉兰-巴雷综合征”“蛋白尿”“肾病综合征”“肾病”“肾脏疾病”“肾小球肾炎”“膜性肾病”“自身免疫性结节病”和“膜性肾小球肾炎”等医学主题词（MeSH），在包括PubMed和EMBASE在内的多个在线数据库中进行了全面检索。我们回顾了截至2024年10月的出版物，确定了39例患有抗接触蛋白相关慢性炎症性脱髓鞘性多发性神经根神经病（CIDP）并伴有膜性肾小球肾炎（MGN）的患者，包括我们的病例。这种罕见的共存情况通常发生在老年，仅有两例儿科病例。无论发病年龄如何，临床特征相似。我们比较了儿科和成人患者的发病情况、症状、病情进展、肾脏组织病理学和治疗反应。
