Pulmonology Department, Toulouse University Hospital, Toulouse, France.
Paul Sabatier III Toulouse University, Toulouse, France.
Respirology. 2024 Jun;29(6):505-512. doi: 10.1111/resp.14697. Epub 2024 Mar 3.
EpiGETIF is a web-based, multicentre clinical database created in 2019 aiming for prospective collection of data regarding therapeutic rigid bronchoscopy (TB) for malignant central airway obstruction (MCAO).
Patients were enrolled into the registry from January 2019 to November 2022. Data were prospectively entered through a web-interface, using standardized definitions for each item. The objective of this first extraction of data was to describe the population and the techniques used among the included centres to target, facilitate and encourage further studies in TB.
Overall, 2118 patients from 36 centres were included. Patients were on average 63.7 years old, mostly male and smokers. Most patients had a WHO score ≤2 (70.2%) and 39.6% required preoperative oxygen support, including mechanical ventilation in 6.7%. 62.4% had an already known histologic diagnosis but only 46.3% had received any oncologic treatment. Most tumours were bronchogenic (60.6%), causing mainly intrinsic or mixed obstruction (43.3% and 41.5%, respectively). Mechanical debulking was the most frequent technique (67.3%), while laser (9.8%) and cryo-recanalization (2.7%) use depended on local expertise. Stenting was required in 54.7%, silicone being the main type of stent used (55.3%). 96.3% of procedure results were considered at least partially successful, resulting in a mean 4.1 points decrease on the Borg scale of dyspnoea. Complications were noted in 10.9%.
This study exposes a high volume of TB that could represent a good source of future studies given the dismal amount of data about the effects of TB in certain populations and situations.
EpiGETIF 是一个基于网络的多中心临床数据库，创建于 2019 年，旨在前瞻性收集关于治疗性硬质支气管镜（TB）治疗恶性中央气道阻塞（MCAO）的数据。
从 2019 年 1 月至 2022 年 11 月，患者被纳入该登记处。通过网络界面前瞻性地输入数据，每个项目都使用标准化定义。本次数据提取的目的是描述纳入中心的人群和使用的技术，以针对、促进和鼓励 TB 的进一步研究。
总体而言，来自 36 个中心的 2118 名患者被纳入。患者平均年龄为 63.7 岁，主要为男性和吸烟者。大多数患者的世界卫生组织（WHO）评分≤2（70.2%），39.6%需要术前吸氧支持，包括 6.7%的机械通气。62.4%有已明确的组织学诊断，但只有 46.3%接受过任何肿瘤治疗。大多数肿瘤为支气管源性（60.6%），主要引起内在或混合性阻塞（分别为 43.3%和 41.5%）。机械切除术是最常见的技术（67.3%），而激光（9.8%）和冷冻再通术（2.7%）的使用取决于当地的专业知识。需要支架置入的患者占 54.7%，使用的主要支架类型为硅胶（55.3%）。96.3%的手术结果被认为至少部分成功，导致 Borg 呼吸困难量表评分平均下降 4.1 分。10.9%的患者发生了并发症。
这项研究显示了大量的 TB 治疗，考虑到在某些人群和情况下，关于 TB 效果的数据非常有限，这些治疗可能是未来研究的良好来源。
