Institute of Chemical Technology and Engineering, Poznan University of Technology, Poznan, Poland.
Institute of Physics, Faculty of Materials Engineering and Technical Physics, Poznan University of Technology, Poznan, Poland.
J Biomed Mater Res B Appl Biomater. 2024 Mar;112(3):e35395. doi: 10.1002/jbm.b.35395.
6-Mercaptopurine (6MP) is commonly used in the treatment of acute lymphoblastic leukemia as an important agent in maintenance therapy. Despite its therapeutic benefits, 6MP has some limitations during therapy. Taking into account the disadvantages during 6MP therapy, there is a great need to create an appropriate delivery system for this drug. 6MP contains in its structure nitrogen and sulfur atoms capable of forming coordination compounds with metal ions, for example zinc. Therefore, in this work, we prepared biocompatible hydroxyapatite (HAp) doped with zinc ions, and used it as a carrier for 6MP. Doped HAp has not been used as a carrier for this drug before. The work proved that the prepared carrier-drug system has a particle size of about 130 nm, which indicates its potential for intravenous delivery. In addition, in an acidic environment (imitating cancer cells), the carrier agglomerates allow targeted release of the drug. The drug is evenly distributed, which indicates that the doses released from it will always be comparable. The release of the drug in a neutral environment is long-lasting in controlled doses, whereas in an acidic environment it is immediate. The obtained results indicate the high potential of the material in both slow-release and cancer-targeted release of 6MP.
巯嘌呤（6MP）是治疗急性淋巴细胞白血病的常用药物，是维持治疗中的重要药物。尽管 6MP 具有治疗作用，但在治疗过程中也存在一些局限性。考虑到 6MP 治疗期间的这些缺点，非常需要为这种药物创建一种合适的传递系统。6MP 结构中含有氮和硫原子，能够与金属离子形成配位化合物，例如锌。因此，在这项工作中，我们制备了掺锌的生物相容性羟基磷灰石（HAp），并将其用作 6MP 的载体。之前尚未将掺杂的 HAp 用作这种药物的载体。该研究证明，所制备的载药体系的粒径约为 130nm，表明其具有静脉给药的潜力。此外，在酸性环境（模拟癌细胞）中，载体聚集允许药物的靶向释放。药物分布均匀，这表明从其中释放的剂量将始终保持可比。在中性环境中，药物的释放是持续的，剂量得到控制，而在酸性环境中则是即刻释放。所得结果表明，该材料在 6MP 的缓慢释放和癌症靶向释放方面具有很高的潜力。
