Zhang Xing-Yu, Guo Qi, Chen Xiao-Yu
College of Rehabilitation Sciences,Shanghai University of Medicine & Health Sciences,Shanghai 201318,China.
Tianjin Key Laboratory of Exercise Physiology and Sports Medicine,Institute of Sport, Exercise & Health,Tianjin University of Sport,Tianjin 301617,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2024 Feb;46(1):111-118. doi: 10.3881/j.issn.1000-503X.15521.
Sarcopenia is an age-related condition characterized by a decrease in muscle mass and a decline in muscle strength.Sarcopenia increases the risk of falls,severely affecting the quality of life of patients,and it may be associated with various age-related chronic diseases.Advanced glycation end products(AGEs)are a class of stable glycation products produced by condensation,rearrangement,cleavage,and oxidative modification between the free amino groups of proteins,lipids or nucleic acids and the free carbonyl groups of reducing sugars.Studies have revealed associations of AGEs with muscle mass,muscle strength,and sarcopenia.AGEs can lead to hardening of the extracellular matrix of skeletal muscle through glycation cross-linking.The binding of AGEs to receptors induces inflammation and oxidative stress,consequently resulting in decreases in muscle mass and muscle strength.Therefore,AGEs may play a role in the occurrence and development of sarcopenia.This review summarizes the role of AGEs in the pathogenesis of sarcopenia,offering theoretical support for probing into the mechanisms underlying sarcopenia.
肌肉减少症是一种与年龄相关的病症，其特征是肌肉质量下降和肌肉力量减退。肌肉减少症会增加跌倒风险，严重影响患者的生活质量，并且可能与各种年龄相关的慢性疾病有关。晚期糖基化终产物（AGEs）是一类稳定的糖基化产物，由蛋白质、脂质或核酸的游离氨基与还原糖的游离羰基之间通过缩合、重排、裂解和氧化修饰产生。研究已经揭示了AGEs与肌肉质量、肌肉力量和肌肉减少症之间的关联。AGEs可通过糖基化交联导致骨骼肌细胞外基质硬化。AGEs与受体的结合会诱导炎症和氧化应激，从而导致肌肉质量和肌肉力量下降。因此，AGEs可能在肌肉减少症的发生和发展中起作用。本综述总结了AGEs在肌肉减少症发病机制中的作用，为探究肌肉减少症的潜在机制提供理论支持。
