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[12例面神经肿瘤的预后分析]

[Analysis of the outcome of 12 cases of facial nerve tumors].

作者信息

Shao Zhangtao, Zhou Ming, Yang Jianghui, Wang Kai

机构信息

Health Science Center,Ningbo University,Ningbo,315211,China.

Department of Otolaryngology,Ningbo Second Hospital.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2024 Mar;38(3):225-229. doi: 10.13201/j.issn.2096-7993.2024.03.009.

Abstract

This study aims to provide a comprehensive summary of the pathogenesis, screening modalities, treatment strategies, repair modalities and preliminary results associated with facial nerve tumors. A retrospective analysis was conducted on the clinical data of 12 patients with facial nerve tumors who were admitted to our department between May 2018 and February 2023. The study population consisted of 5 males and 7 females, with ages ranging from 35 to 90 years. Clinical symptoms observed in these patients included facial nerve palsy, hearing loss, tinnitus, headache, and otalgia, etc. The severity of facial nerve dysfunction was assessed using the House-Brackmann(H-B) facial nerve function classification, with 3 cases classified as grade Ⅰ, 4 cases as grade Ⅲ, 2 cases as grade Ⅳ, and 3 cases as grade Ⅴ. There was a total of 11 patients who presented with hearing loss. Among these patients, 7 cases were diagnosed with conductive hearing loss, 2 cases with sensorineural hearing loss, and 2 cases with mixed hearing loss. The selection of the observation or surgical route for tumor localization was based on clinical symptoms, facial nerve function grading, and imaging examination results including temporal bone CT and enhanced MRI. Specifically, the location of the tumor was selected for observation or the best surgical route: 2 cases were followed up for observation, 1 case underwent biopsy, and 9 cases underwent tumor resection(7 cases of trans-mastoid approach, 2 cases of combined parotid-mastoidal approach), concurrent repair of the facial nerve(4 cases of auricular nerve grafting, 3 cases of facial nerve diversion anastomosis, 2 cases of peroneal nerve grafting). (4 cases of auricular nerve graft, 3 cases of facial nerve diversion anastomosis and 2 cases of peroneal nerve grafting). Periodic postoperative evaluation of facial nerve function was conducted. 1-year follow-up was available. Intraoperatively, it was observed that 66.7%(6 out of 9) of the facial nerve tumors were present in multiple segments. Among these segments, the vertical segment had the highest proportion, accounting for 77.8%(7 out of 9), followed by the labyrinthine segment/geniculate ganglion with 66.7%(6 out of 9) and the horizontal segment with 55.6%(5 out of 9). Postoperative pathology confirmed 8 cases with nerve sheath meningioma, Ⅰ with seminal fibroma and 1 with hemangioma. Postoperative facial nerve function was graded as H-B grade I in one patient), grade Ⅲ in three, grade Ⅳ in four, grade Ⅴ in 2, and grade Ⅵ in 2 patients. The auditory outcomes following surgery are as follows: 8 individuals experienced postoperative hearing loss, while 2 individuals demonstrated postoperative hearing preservation. In the case of patients presenting with facial nerve palsy as their initial symptom, it is imperative to consider the potential presence of a facial nerve tumor. To determine the appropriate course of action, it is necessary to ascertain the size and location of the tumors through imaging examinations. This information will aid in the decision making process regarding whether surgical intervention is warranted, and so, the most suitable approach. Additionally, the choice of repair method during the operation should be guided by the extent of facial nerve defect.

摘要

本研究旨在全面总结面神经肿瘤的发病机制、筛查方式、治疗策略、修复方式及初步结果。对2018年5月至2023年2月期间收治于我科的12例面神经肿瘤患者的临床资料进行回顾性分析。研究对象包括5例男性和7例女性,年龄在35岁至90岁之间。这些患者观察到的临床症状包括面神经麻痹、听力丧失、耳鸣、头痛和耳痛等。采用House-Brackmann(H-B)面神经功能分级评估面神经功能障碍的严重程度,其中3例为Ⅰ级,4例为Ⅲ级,2例为Ⅳ级,3例为Ⅴ级。共有11例患者出现听力丧失。在这些患者中,7例诊断为传导性听力丧失,2例为感音神经性听力丧失,2例为混合性听力丧失。根据临床症状、面神经功能分级以及颞骨CT和增强MRI等影像学检查结果选择肿瘤定位的观察或手术路径。具体而言,根据肿瘤位置选择观察或最佳手术路径:2例进行随访观察,1例进行活检,9例进行肿瘤切除(7例采用经乳突入路,2例采用腮腺-乳突联合入路),同时进行面神经修复(4例采用耳大神经移植,3例采用面神经改道吻合,2例采用腓总神经移植)。(4例耳大神经移植,3例面神经改道吻合,2例腓总神经移植)。术后定期对面神经功能进行评估。有1年的随访资料。术中观察到,9例面神经肿瘤中有66.7%(6例)为多节段存在。在这些节段中,垂直段比例最高,占77.8%(7例),其次是迷路段/膝状神经节,占66.7%(6例),水平段占55.6%(5例)。术后病理证实8例为神经鞘膜瘤,1例为精原细胞瘤,1例为血管瘤。术后面神经功能分级为:1例患者为H-B Ⅰ级,3例为Ⅲ级,4例为Ⅳ级,2例为Ⅴ级,2例为Ⅵ级。术后听觉结果如下:8例患者术后听力丧失,2例患者术后听力保留。对于以面神经麻痹为首发症状的患者,必须考虑面神经肿瘤的可能性。为确定适当的行动方案,有必要通过影像学检查确定肿瘤的大小和位置。这些信息将有助于决定是否需要手术干预以及最合适的手术方法。此外,手术中修复方法的选择应根据面神经缺损的程度来指导。

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