Huang A Y, Chai Y C, Xue L, Chen H S, Hu L X, Jia H, Zhang Z H, Wu H, Wang Z Y
Department of Otolaryngology Head and Neck Surgery,Shanghai Ninth People's Hospital,Shanghai Jiaotong University School of Medicine, Shanghai 200011, China Ear Institute,Shanghai Jiaotong University School of Medicine, Shanghai 200092, China Shanghai Key Laboratory of Translational Medicine on Ear and Nose diseases,Shanghai 200092,China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Jul 7;57(7):819-826. doi: 10.3760/cma.j.cn115330-20210629-00389.
To investigate the clinical characteristics, differential diagnosis, treatments and prognosis of facial nerve hemangioma and schwannoma at genicular ganglion, so as to provide reference for clinical diagnosis and treatments of facial nerve tumor at genicular ganglion. Clinical data of 13 patients with facial nerve tumors at genicular ganglion confirmed by postoperative pathology in the Ninth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine from March 2018 to April 2020 were retrospectively analyzed, including seven cases of hemangioma and six cases of schwannoma. There were eight males and five females. Their ages ranged from 20 to 65, with an average age of 40. The course of disease ranged from 3 to 118 months, with an average of 52 months. All the patients underwent preoperative HRCT of the temporal bone and facial nerve dynamic contrast-enhanced(DCE) MRI examinations. All the patients had detailed surgical procedures and at least one-year postoperative follow-up. On HRCT of the temporal bone, (4/7) hemangioma at geniculate ganglion showed characteristic honeycomb appearance, while 6/6 schwannoma and 3/7 hemangiomas showed expansive bone changes. On DCE-MRI, geniculate ganglion hemangioma (7/7) showed characteristic "point-to-surface" enhancement, and schwannoma (6/6) showed characteristic "face-to-surface" enhancement. For five hemangioma-patients with HB-Ⅱ-Ⅳ before surgery, the facial nerve anatomy was completely preserved through transcanal endoscopic approach(TEA), and the facial nerve function improved one year after surgery (two cases of HB-I, two cases of HB-Ⅱ, and one case of HB-Ⅲ). For two patients, with preoperative facial nerve function HB-Ⅴ-Ⅵ, since their tumors was inseparable from the nerves, they were performed with facial nerve anastomosis during the surgery, and the facial nerve function was improved to HB-Ⅳ level one year after surgery. For six patients with meningioma whose facial nerve function was greater than or equal to HB-Ⅲ, based on the preoperative hearing level, the involved segments, and duration of facial paralysis, three of them were conducted surgeries through middle cranial fossa approach, one by translabyrinthine approach, and one via mastoid approach. Two patients among them with complete facial paralysis over three years preoperatively were not performed facial nerve anastomosis after total resections of the tumors, and there was no improvement in facial nerve function one year after surgery. Three patients underwent facial nerve anastomosis after total tumor resections, and their facial nerve function was HB-Ⅲ in one patient, HB-Ⅳ in two patients one year after surgery. One patient (preoperative HB-Ⅲ) had a normal hearing level preoperatively, and the tumor involved the labyrinth segment. To protect the hearing, partial tumor was resected through the middle cranial fossa approach, and facial nerve function improved to HB-Ⅱ one year after surgery. Temporal bone HRCT combined with DCE-MRI are useful for the differential diagnosis of hemangioma and schwannoma at geniculate ganglion and provide references for preoperative clinical decision makings. It is extremely necessary to select the appropriate surgical approach based on the patient's hearing and involved segments. For geniculate ganglion hemangioma, early surgery can improve the possibilities of anatomical integrity of facial nerve, thereby improving facial nerve function postoperatively.TEA is a kind of surgical method worth consideration, with the characteristics of minimally invasive, favorable postoperative features, and so on. For schwannoma, one-stage functional reconstruction of the facial nerve is recommended during the resection of the tumors because of the inevitable damage to the anatomical integrity of the facial nerve.
探讨膝状神经节面神经血管瘤与神经鞘瘤的临床特点、鉴别诊断、治疗方法及预后,为膝状神经节面神经肿瘤的临床诊断与治疗提供参考。回顾性分析2018年3月至2020年4月上海交通大学医学院附属第九人民医院经术后病理确诊的13例膝状神经节面神经肿瘤患者的临床资料,其中血管瘤7例,神经鞘瘤6例。男8例,女5例。年龄20~65岁,平均40岁。病程3~118个月,平均52个月。所有患者均行颞骨高分辨率CT(HRCT)及面神经动态对比增强(DCE)磁共振成像(MRI)检查。所有患者均接受了详细的手术治疗,并进行了至少1年的术后随访。在颞骨HRCT上,膝状神经节血管瘤4/7表现为特征性的蜂窝状外观,而6/6神经鞘瘤和3/7血管瘤表现为骨质膨胀性改变。在DCE-MRI上,膝状神经节血管瘤7/7表现为特征性的“点对面”强化,神经鞘瘤6/6表现为特征性的“面对面”强化。5例术前为HB-Ⅱ-Ⅳ级的血管瘤患者,经耳道内镜入路(TEA)完全保留面神经解剖结构,术后1年面神经功能改善(2例HB-I级,2例HB-Ⅱ级,1例HB-Ⅲ级)。2例术前面神经功能为HB-Ⅴ-Ⅵ级的患者,因肿瘤与神经粘连紧密,术中行面神经吻合术,术后1年面神经功能改善至HB-Ⅳ级。6例面神经功能≥HB-Ⅲ级的神经鞘瘤患者,根据术前听力水平、肿瘤累及节段及面瘫时间,3例行中颅窝入路手术,1例行迷路入路手术,1例行乳突入路手术。其中2例术前完全性面瘫超过3年的患者,肿瘤全切术后未行面神经吻合术,术后1年面神经功能无改善。3例肿瘤全切术后行面神经吻合术,术后1年1例患者面神经功能为HB-Ⅲ级,2例为HB-Ⅳ级。1例术前HB-Ⅲ级患者术前听力正常,肿瘤累及迷路段,为保护听力,经中颅窝入路行部分肿瘤切除,术后1年面神经功能改善至HB-Ⅱ级。颞骨HRCT联合DCE-MRI有助于膝状神经节血管瘤与神经鞘瘤的鉴别诊断,为术前临床决策提供参考。根据患者听力及肿瘤累及节段选择合适的手术入路非常必要。对于膝状神经节血管瘤,早期手术可提高面神经解剖完整性的可能性,从而改善术后面神经功能。TEA是一种值得考虑的手术方法,具有微创、术后恢复良好等特点。对于神经鞘瘤,由于手术中不可避免地会对面神经解剖完整性造成破坏,建议在肿瘤切除术中一期进行面神经功能重建。