Bohne Jens, Salloch Sabine, Gabriel Martin, Abad Xavier, Mertsching Jürgen
Department of Biosafety, Hannover Medical School, Hannover, Germany.
Institute of Virology, Hannover Medical School, Hannover, Germany.
Appl Biosaf. 2024 Mar 1;29(1):26-34. doi: 10.1089/apb.2023.0015. Epub 2024 Feb 28.
The current global situation with increasing zoonotic transmissions of pathogens, rapidly changing ecosystems due to the climate change and with it the distribution of potential vectors, demands new ways of teaching and educating students in the field of infectious disease research.
The international master program "Infectious Diseases and One Health-IDOH" started its second application period in 2019. Biosafety is an integral part of IDOH, exemplified by a biosafety level 3 hands-on training at the Animal Health Research Center IRTA-Centre de Recerca en Sanitat Animal (CReSA), Barcelona. At Hanover Medical School, biosafety is expanded to a comprehensive biorisk management approach with focus on risk assessment, bioethics, and training in a mobile containment laboratory. This article illustrates in depth the intention and the individual teaching units of the biorisk management module within the third semester of the IDOH master. Risk assessment is taught based on the new WHO Laboratory Biosafety Manual 4th edition, which represents a paradigm shift toward a risk-based approach instead of a prescriptive definition of biosafety levels. This methodology will enable the international IDOH students to cope with different national legislations and to provide guidance on biosafety in their home countries. In the final unit, the students operate a mobile containment laboratory and simulated a viral hemorrhagic fever outbreak in Africa.
In sum, this module combines theoretical risk assessment and its practical implementation in the mobile laboratory as a future direction for training infectiologists. In addition, our report may serve as a blue print for others to amend their education with the herewith mentioned pillars of biosafety teaching.
当前全球形势下,病原体的人畜共患病传播不断增加,气候变化导致生态系统迅速变化,随之而来的是潜在病媒的分布变化,这就需要在传染病研究领域采用新的教学方法来培养学生。
国际硕士项目“传染病与同一健康-IDOH”于2019年开始第二个申请期。生物安全是IDOH的一个组成部分,例如在巴塞罗那的动物健康研究中心IRTA-动物卫生研究中心(CReSA)进行的3级生物安全实践培训。在汉诺威医学院,生物安全扩展为一种全面的生物风险管理方法,重点是风险评估、生物伦理学以及在移动隔离实验室中的培训。本文深入阐述了IDOH硕士第三学期生物风险管理模块的意图和各个教学单元。风险评估是根据世界卫生组织新版《实验室生物安全手册》第4版进行教学的,该手册代表了从基于规定性生物安全等级定义向基于风险方法的范式转变。这种方法将使IDOH的国际学生能够应对不同国家的法规,并为其本国的生物安全提供指导。在最后一个单元中,学生操作一个移动隔离实验室,并模拟了非洲的病毒性出血热疫情爆发。
总之,该模块将理论风险评估及其在移动实验室中的实际应用结合起来,作为培养传染病学家的未来方向。此外,我们的报告可为其他人以本文所述的生物安全教学支柱来改进其教育提供蓝本。