Erickson Nathan E N, Lacoste Stacey, Sniatynski Michelle, Waldner Cheryl, Ellis John
Department of Large Animal Clinical Sciences (Erickson, Lacoste, Waldner) and Department of Microbiology (Sniatynski, Ellis), Western College of Veterinary Medicine, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4; Vaccine and Infectious Disease Organization, 120 Veterinary Road, Saskatoon, Saskatchewan S7N 5E3 (Sniatynski).
Can Vet J. 2024 Mar;65(3):250-258.
This study addressed the current gap in knowledge of neonatal prime-boost immune responses for the control of bovine coronavirus (BCoV) respiratory disease in weaning-age beef cattle.
Study 1 and Study 2 had 33 and 22 commercial cross neonatal beef calves, respectively.
Study 1 compared BCoV-neutralizing antibody concentrations of control calves with 3 groups of calves differentially vaccinated with mucosal and/or systemic BCoV modified live virus (MLV) vaccines. Study 2 compared specific and neutralizing antibody concentrations among mucosally BCoV primed groups of calves that were differentially systemically boosted.
In Study 1, calves that were mucosally primed and systemically boosted had higher BCoV-neutralizing antibody concentrations than the control group at weaning. In Study 2, boosting mucosally primed calves by injecting inactivated or MLV vaccine resulted in anamnestic BCoV-specific antibody responses at weaning.
Neonatal mucosal priming and systemic boosting resulted in anamnestic BCoV antibody responses at weaning.
Prime-boost vaccination should be considered for control of BCoV respiratory disease.
本研究解决了当前在断奶期肉牛中控制牛冠状病毒（BCoV）呼吸道疾病的新生儿初次-加强免疫反应知识方面的空白。
研究1和研究2分别有33头和22头商业杂交新生肉牛犊。
研究1比较了对照组犊牛与3组分别用粘膜和/或全身BCoV改良活病毒（MLV）疫苗进行不同接种的犊牛的BCoV中和抗体浓度。研究2比较了经粘膜BCoV初免的犊牛组中，经不同全身加强免疫后的特异性和中和抗体浓度。
在研究1中，经粘膜初免和全身加强免疫的犊牛在断奶时的BCoV中和抗体浓度高于对照组。在研究2中，通过注射灭活疫苗或MLV疫苗对经粘膜初免的犊牛进行加强免疫，在断奶时产生了BCoV特异性抗体的回忆反应。
新生儿粘膜初免和全身加强免疫在断奶时产生了BCoV抗体的回忆反应。
应考虑采用初免-加强免疫接种来控制BCoV呼吸道疾病。
