Zhou Xintong, Liu Qi, Liu Shihan, Wang Liquan, Sun Zhongli, Sun Changgang, Cui Xiangning
College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Otorhinolaryngology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Front Oncol. 2024 Feb 16;14:1321445. doi: 10.3389/fonc.2024.1321445. eCollection 2024.
Patients with schizophrenia are at a higher risk of developing cancer. However, the causal relationship between schizophrenia and different tumor types remains unclear.
Using a two-sample, two-way Mendelian randomization method, we used publicly available genome-wide association analysis (GWAS) aggregate data to study the causal relationship between schizophrenia and different cancer risk factors. These tumors included lung adenocarcinoma, lung squamous cell carcinoma, small-cell lung cancer, gastric cancer, alcohol-related hepatocellular cancer, tumors involving the lungs, breast, thyroid gland, pancreas, prostate, ovaries and cervix, endometrium, colon and colorectum, and bladder. We used the inverse variance weighting (IVW) method to determine the causal relationship between schizophrenia and different tumor risk factors. In addition, we conducted a sensitivity test to evaluate the effectiveness of the causality.
After adjusting for heterogeneity, evidence of a causal relationship between schizophrenia and lung cancer risk was observed (odds ratio [OR]=1.001, 95% confidence interval [CI], 1.000-1.001; =0.0155). In the sensitivity analysis, the causal effect of schizophrenia on the risk of lung cancer was consistent in both direction and degree. However, no evidence of causality or reverse causality between schizophrenia and other tumors was found.
This study elucidated a causal relationship between the genetic predictors of schizophrenia and the risk of lung cancer, thereby providing a basis for the prevention, pathogenesis, and treatment of schizophrenia in patients with lung cancer.
精神分裂症患者患癌症的风险更高。然而，精神分裂症与不同肿瘤类型之间的因果关系仍不清楚。
我们使用两样本、双向孟德尔随机化方法，利用公开可用的全基因组关联分析（GWAS）汇总数据，研究精神分裂症与不同癌症风险因素之间的因果关系。这些肿瘤包括肺腺癌、肺鳞状细胞癌、小细胞肺癌、胃癌、酒精相关性肝细胞癌、涉及肺、乳腺、甲状腺、胰腺、前列腺、卵巢和子宫颈、子宫内膜、结肠和直肠以及膀胱的肿瘤。我们使用逆方差加权（IVW）方法来确定精神分裂症与不同肿瘤风险因素之间的因果关系。此外，我们进行了敏感性测试以评估因果关系的有效性。
在调整异质性后，观察到精神分裂症与肺癌风险之间存在因果关系的证据（优势比[OR]=1.001，95%置信区间[CI]，1.000 - 1.001；P = 0.0155）。在敏感性分析中，精神分裂症对肺癌风险的因果效应在方向和程度上都是一致的。然而，未发现精神分裂症与其他肿瘤之间存在因果关系或反向因果关系的证据。
本研究阐明了精神分裂症的遗传预测因素与肺癌风险之间的因果关系，从而为肺癌患者精神分裂症的预防、发病机制和治疗提供了依据。
