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局部应用5-氟尿嘧啶继发的角膜内皮毒性

Corneal Endothelial Toxicity Secondary to Topical 5-fluorouracil.

作者信息

Alsaleh Ahmed, Alfarhan Abdulrahman

机构信息

Anterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

出版信息

Middle East Afr J Ophthalmol. 2024 Jan 22;30(1):55-58. doi: 10.4103/meajo.meajo_33_23. eCollection 2023 Jan-Mar.

DOI:10.4103/meajo.meajo_33_23
PMID:38435104
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10903716/
Abstract

5-fluorouracil (5-FU) is an important chemotherapy adjunct for the management of conjunctival and corneal dysplasia. Since it is possible for this agent to gain access to the anterior chamber, several reports in the literature have demonstrated 5-FU long-term safety and efficacy. Although recent publications reported that topical 5-FU has no cytotoxic effect on the corneal endothelium, we report a patient affected by bilateral ocular surface squamous neoplasia who has developed significant endothelial density and morphology changes after starting a course of 5-FU.

摘要

5-氟尿嘧啶（5-FU）是治疗结膜和角膜发育异常的重要化疗辅助药物。由于该药物有可能进入前房，文献中的几篇报道已证实了5-FU的长期安全性和有效性。尽管最近的出版物报道局部应用5-FU对角膜内皮没有细胞毒性作用，但我们报告了一名双侧眼表鳞状细胞瘤患者，在开始使用一个疗程的5-FU后出现了明显的内皮密度和形态变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/882d/10903716/2d5dbd2da04f/MEAJO-30-55-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/882d/10903716/d6303046e07e/MEAJO-30-55-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/882d/10903716/c9644a5f1622/MEAJO-30-55-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/882d/10903716/2d5dbd2da04f/MEAJO-30-55-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/882d/10903716/d6303046e07e/MEAJO-30-55-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/882d/10903716/c9644a5f1622/MEAJO-30-55-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/882d/10903716/2d5dbd2da04f/MEAJO-30-55-g003.jpg

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1
Corneal Endothelial Toxicity Secondary to Topical 5-fluorouracil.局部应用5-氟尿嘧啶继发的角膜内皮毒性
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2
Topical 5-fluorouracil in treating epithelial neoplasia of the conjunctiva and cornea.局部应用5-氟尿嘧啶治疗结膜和角膜上皮肿瘤。
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J Oncol Pharm Pract. 2023 Jun;29(4):975-979. doi: 10.1177/10781552221125763. Epub 2022 Sep 21.
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The effects of 5-fluorouracil and mitomycin C on the corneal endothelium.5-氟尿嘧啶和丝裂霉素C对角膜内皮的影响。
Curr Eye Res. 1992 Jun;11(6):565-70. doi: 10.3109/02713689209001812.
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Topical chemotherapy for giant ocular surface squamous neoplasia of the conjunctiva and cornea: Is surgery necessary?结膜和角膜巨大眼表鳞状细胞瘤的局部化疗：是否需要手术？
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5-Fluorouracil for the treatment of intraepithelial neoplasia of the conjunctiva and cornea.5-氟尿嘧啶用于治疗结膜和角膜上皮内瘤变。
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Topical 1% 5-fluoruracil as a sole treatment of corneoconjunctival ocular surface squamous neoplasia: long-term study.局部应用1%氟尿嘧啶作为角膜结膜眼表鳞状上皮肿瘤的单一治疗方法：长期研究
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Br J Ophthalmol. 2011 Mar;95(3):355-9. doi: 10.1136/bjo.2010.183244. Epub 2010 Aug 7.

本文引用的文献

1
Topical 5-Fluorouracil 1% as Primary Treatment for Ocular Surface Squamous Neoplasia.1%的局部用氟尿嘧啶作为眼表鳞状上皮肿瘤的主要治疗方法
Ophthalmology. 2016 Jul;123(7):1442-8. doi: 10.1016/j.ophtha.2016.02.034. Epub 2016 Mar 27.
2
Ocular surface squamous neoplasia: a survey of changes in the standard of care from 2003 to 2012.眼表鳞状细胞肿瘤：2003 年至 2012 年护理标准变化的调查。
Cornea. 2013 Dec;32(12):1558-61. doi: 10.1097/ICO.0b013e3182a6ea6c.
3
Topical 1% 5-fluorouracil in ocular surface squamous neoplasia: a long-term safety study.
眼表鳞状细胞肿瘤中局部使用 1% 5-氟尿嘧啶：一项长期安全性研究。
Br J Ophthalmol. 2011 Mar;95(3):355-9. doi: 10.1136/bjo.2010.183244. Epub 2010 Aug 7.
4
Effect of topical mitomycin C on corneal endothelium.局部应用丝裂霉素C对角膜内皮的影响。
Am J Ophthalmol. 2008 Apr;145(4):635-638. doi: 10.1016/j.ajo.2007.12.004. Epub 2008 Feb 1.
5
The clinical applications of fluorouracil in ophthalmic practice.氟尿嘧啶在眼科临床中的应用。
Drugs. 2007;67(2):237-55. doi: 10.2165/00003495-200767020-00005.
6
Topical medical therapies for ocular surface tumors.眼表肿瘤的局部药物治疗
Semin Ophthalmol. 2006 Jul-Sep;21(3):161-9. doi: 10.1080/08820530500351694.
7
Ocular surface squamous neoplasia: a standard of care survey.眼表鳞状上皮肿瘤：一项护理标准调查。
Cornea. 2005 Apr;24(3):297-300. doi: 10.1097/01.ico.0000138834.42489.ba.
8
Successful treatment with 5-fluorouracil of conjunctival intraepithelial neoplasia refractive to mitomycin-C.对丝裂霉素C耐药的结膜上皮内瘤用5-氟尿嘧啶成功治疗。
Ophthalmology. 2002 Feb;109(2):249-52. doi: 10.1016/s0161-6420(01)00926-5.
9
5-Fluorouracil for the treatment of intraepithelial neoplasia of the conjunctiva and cornea.5-氟尿嘧啶用于治疗结膜和角膜上皮内瘤变。
Ophthalmology. 2000 Dec;107(12):2190-5. doi: 10.1016/s0161-6420(00)00389-4.
10
Treatment of conjunctival squamous cell carcinoma with topical 5-fluorouracil.局部应用5-氟尿嘧啶治疗结膜鳞状细胞癌。
Br J Ophthalmol. 2000 Mar;84(3):268-72. doi: 10.1136/bjo.84.3.268.