Cankurtaran Rasim Eren, Ersoy Osman
Department of Gastroenterology, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, TUR.
Department of Gastroenterology, School of Medicine, Ankara Yildirim Beyazit University, Ankara, TUR.
Cureus. 2024 Feb 1;16(2):e53375. doi: 10.7759/cureus.53375. eCollection 2024 Feb.
Background and aims In this study, we aimed to investigate the frequency of adverse events (AEs) in patients undergoing endoscopic retrograde cholangiopancreticography (ERCP) for choledocholithiasis and the independent risk factors that may cause these conditions. We planned to evaluate all AEs including cardiopulmonary complications and the risk factors that may affect them holistically. Methods This study was designed as a retrospective cohort study conducted at a single tertiary center's gastroenterology clinic. The study included patients with naive papillae and undergoing ERCP for choledocholithiasis between May 2019 and June 2022. Risk factors that may lead to AEs were analyzed in terms of both patient-related factors and procedure-related factors. Patients with and without AEs after ERCP were compared. Results This study included 812 patients who underwent ERCP for choledocholithiasis. AE occurred in 149 (18.3%) of patients, and the most common complication was pancreatitis (n=112, 13.8%). In regression analysis, of the patient- and procedure-related factors, only difficult cannulation was a significant independent risk factor for AEs (odds ratio=3.85, 95% CI: 1.102-13.498, p=0.035). Conclusion This study showed that, of patient- and procedure-related factors, only difficult cannulation is an independent risk factor for ERCP-related AEs.
背景与目的 在本研究中，我们旨在调查因胆总管结石接受内镜逆行胰胆管造影术（ERCP）的患者中不良事件（AE）的发生频率以及可能导致这些情况的独立危险因素。我们计划全面评估所有不良事件，包括心肺并发症以及可能影响它们的危险因素。方法 本研究设计为在一家三级中心的胃肠病诊所进行的回顾性队列研究。该研究纳入了2019年5月至2022年6月间乳头正常且因胆总管结石接受ERCP的患者。从患者相关因素和操作相关因素两方面分析可能导致不良事件的危险因素。比较ERCP术后发生和未发生不良事件的患者。结果 本研究纳入了812例因胆总管结石接受ERCP的患者。149例（18.3%）患者发生了不良事件，最常见的并发症是胰腺炎（n = 112，13.8%）。在回归分析中，在患者和操作相关因素中，只有插管困难是不良事件的显著独立危险因素（比值比 = 3.85，95%置信区间：1.102 - 13.498，p = 0.035）。结论 本研究表明，在患者和操作相关因素中，只有插管困难是ERCP相关不良事件的独立危险因素。
