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内镜逆行胰胆管造影(ERCP)相关不良事件:欧洲胃肠道内镜学会(ESGE)指南。

ERCP-related adverse events: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.

机构信息

Gastroenterology Service, Hôpital Civil Marie Curie, Charleroi, Belgium.

Department of Gastroenterology and Hepatology, Ordensklinikum Barmherzige Schwestern, Linz, Austria.

出版信息

Endoscopy. 2020 Feb;52(2):127-149. doi: 10.1055/a-1075-4080. Epub 2019 Dec 20.

DOI:10.1055/a-1075-4080
PMID:31863440
Abstract

PROPHYLAXIS

1:  ESGE recommends routine rectal administration of 100 mg of diclofenac or indomethacin immediately before endoscopic retrograde cholangiopancreatography (ERCP) in all patients without contraindications to nonsteroidal anti-inflammatory drug administration.Strong recommendation, moderate quality evidence. 2:  ESGE recommends prophylactic pancreatic stenting in selected patients at high risk for post-ERCP pancreatitis (inadvertent guidewire insertion/opacification of the pancreatic duct, double-guidewire cannulation).Strong recommendation, moderate quality evidence. 3:  ESGE suggests against routine endoscopic biliary sphincterotomy before the insertion of a single plastic stent or an uncovered/partially covered self-expandable metal stent for relief of biliary obstruction.Weak recommendation, moderate quality evidence. 4:  ESGE recommends against the routine use of antibiotic prophylaxis before ERCP.Strong recommendation, moderate quality evidence. 5:  ESGE suggests antibiotic prophylaxis before ERCP in the case of anticipated incomplete biliary drainage, for severely immunocompromised patients, and when performing cholangioscopy.Weak recommendation, moderate quality evidence. 6:  ESGE suggests tests of coagulation are not routinely required prior to ERCP for patients who are not on anticoagulants and not jaundiced.Weak recommendation, low quality evidence.

TREATMENT

7:  ESGE suggests against salvage pancreatic stenting in patients with post-ERCP pancreatitis.Weak recommendation, low quality evidence. 8:  ESGE suggests temporary placement of a biliary fully covered self-expandable metal stent for post-sphincterotomy bleeding refractory to standard hemostatic modalities.Weak recommendation, low quality evidence. 9:  ESGE suggests to evaluate patients with post-ERCP cholangitis by abdominal ultrasonography or computed tomography (CT) scan and, in the absence of improvement with conservative therapy, to consider repeat ERCP. A bile sample should be collected for microbiological examination during repeat ERCP.Weak recommendation, low quality evidence.

摘要

预防措施

  1. 对于无非甾体抗炎药使用禁忌的所有患者,ESGE 建议在进行内镜逆行胰胆管造影术(ERCP)前,常规直肠给予 100mg 双氯芬酸或吲哚美辛。强烈推荐,中等质量证据。

  2. ESGE 建议对有发生 ERCP 后胰腺炎(导丝意外插入/胰管显影、双导丝插管)高危风险的患者,预防性胰腺支架置入。强烈推荐,中等质量证据。

  3. ESGE 建议对于缓解胆道梗阻,不常规行内镜下胆道括约肌切开术,除非即将插入单根塑料支架或无覆盖/部分覆盖自膨式金属支架。弱推荐,中等质量证据。

  4. ESGE 建议 ERCP 前不常规使用抗生素预防。强烈推荐,中等质量证据。

  5. ESGE 建议对于预计不完全胆道引流、严重免疫功能低下患者以及进行胆管镜检查时,ERCP 前应使用抗生素预防。弱推荐,中等质量证据。

  6. ESGE 建议对于未接受抗凝治疗且无黄疸的患者,ERCP 前无需常规进行凝血检查。弱推荐,低质量证据。

治疗措施

  1. ESGE 建议对于 ERCP 后胰腺炎患者,不进行挽救性胰腺支架置入。弱推荐,低质量证据。

  2. ESGE 建议对于括约肌切开术后出血,在标准止血方法无效时,临时放置胆道全覆膜自膨式金属支架。弱推荐,低质量证据。

  3. ESGE 建议对于 ERCP 后胆管炎患者,通过腹部超声或计算机断层扫描(CT)进行评估,如果在保守治疗后无改善,考虑再次进行 ERCP。在重复 ERCP 时,应收集胆汁样本进行微生物检查。弱推荐,低质量证据。

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