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异常子宫出血的围绝经期和绝经后女性子宫内膜癌特征分析

Analysis of Characteristics of Endometrial Carcinoma in Peri- and Postmenopausal Women with Abnormal Uterine Bleeding.

作者信息

Yanli Ye, Mei Wang Tian, Cong Li

机构信息

Department of GynecologyNanan People's Hospital of Chongqing, Chongqing 400060, China.

Department of Gynecology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400060, China.

出版信息

Biomed Res Int. 2024 Feb 24;2024:6509171. doi: 10.1155/2024/6509171. eCollection 2024.

DOI:10.1155/2024/6509171
PMID:38435540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10908568/
Abstract

OBJECTIVE

To analyze the menstrual characteristics of endometrial carcinoma and investigate whether abnormal uterine bleeding in the perimenopausal period differs from postmenopausal bleeding.

METHODS

We conducted a retrospective analysis of 928 cases of endometrial carcinoma in patients admitted from January 2016 to December 2022. We gathered fundamental clinical data and analyzed distinct clinical risk factors between the perimenopausal and postmenopausal groups. Furthermore, we computed the statistical variances in menarche, regular menstrual cycles, and the duration of abnormal uterine bleeding.

RESULTS

Perimenopausal patients with endometrial carcinoma exhibit similar factors to postmenopausal patients, especially if they have a history of menstrual cycles lasting more than 30 years, hypertension, abnormal uterine bleeding for over 1 year, and a high risk of endometrial carcinoma. Early intervention for abnormal uterine bleeding during the perimenopausal stage can prevent up to 80% of women from developing endometrial carcinoma.

CONCLUSION

Perimenopause women experiencing abnormal uterine bleeding should be mindful of the risk of endometrial carcinoma, as this awareness can substantially decrease the occurrence of the disease.

摘要

目的

分析子宫内膜癌的月经特征，并调查围绝经期异常子宫出血与绝经后出血是否存在差异。

方法

我们对2016年1月至2022年12月收治的928例子宫内膜癌患者进行了回顾性分析。收集了基本临床数据，并分析了围绝经期和绝经后组之间不同的临床风险因素。此外，我们计算了初潮、月经周期规律以及异常子宫出血持续时间的统计差异。

结果

围绝经期子宫内膜癌患者与绝经后患者表现出相似的因素，尤其是那些月经周期持续超过30年、患有高血压、异常子宫出血超过1年且子宫内膜癌风险高的患者。围绝经期阶段对异常子宫出血进行早期干预可预防高达80%的女性患子宫内膜癌。

结论

围绝经期出现异常子宫出血的女性应注意子宫内膜癌的风险，因为这种意识可大幅降低该疾病的发生率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb9d/10908568/2b2ea1dd384c/BMRI2024-6509171.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb9d/10908568/a7471a835e25/BMRI2024-6509171.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb9d/10908568/c00260c1d31f/BMRI2024-6509171.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb9d/10908568/4a7b6f1d170b/BMRI2024-6509171.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb9d/10908568/2b2ea1dd384c/BMRI2024-6509171.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb9d/10908568/a7471a835e25/BMRI2024-6509171.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb9d/10908568/c00260c1d31f/BMRI2024-6509171.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb9d/10908568/4a7b6f1d170b/BMRI2024-6509171.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb9d/10908568/2b2ea1dd384c/BMRI2024-6509171.004.jpg

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Identifying women 45 years and younger at elevated risk for endometrial hyperplasia or cancer.识别 45 岁及以下的子宫内膜增生或癌症高危女性。
Gynecol Oncol. 2023 Jul;174:98-105. doi: 10.1016/j.ygyno.2023.04.019. Epub 2023 May 10.
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Evaluating Clinical Features in Intracavitary Uterine Pathologies among Vietnamese Women Presenting with Peri-and Postmenopausal Bleeding: A Bicentric Observational Descriptive Analysis.
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Yonsei Med J. 2023 Mar;64(3):197-203. doi: 10.3349/ymj.2022.0239.
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