Zhen Ruoxi, Wang Shuqi, Chen Shuchun
Graduate School of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Department of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Feb 27;17:969-980. doi: 10.2147/DMSO.S447809. eCollection 2024.
This study was designed to analyze correlations between the uric acid to high-density lipoprotein cholesterol ratio (UHR) and peripheral nerve conduction velocity (NCV) among type 2 diabetes mellitus (T2DM) patients.
This was a single-center cross-sectional analysis of 324 T2DM patients. All patients were separated into a group with normal NCV (NCVN) and a group with abnormal NCV (NCVA). Patients were also classified into groups with low and high UHR values based on the median UHR in this study cohort. Neurophysiological data including motor and sensory conduction velocity (MCV and SCV, respectively) were measured for all patients.
Relative to patients with low UHR values, those in the high UHR group presented with greater NCVA prevalence (P = 0.002). UHR remained negatively correlated with bilateral superficial peroneal nerve SCV, bilateral common peroneal nerve MCV, bilateral ulnar nerve SCV, and bilateral right median nerve MCV even after adjustment for confounding factors. UHR was identified as an NCVA-related risk factor, with a 1.370-fold increase in NCVA prevalence for every unit rise in UHR (P < 0.001).
These results identify UHR as a risk factor associated with NCVA that was independently negatively associated with NCV among T2DM patients.
本研究旨在分析2型糖尿病（T2DM）患者尿酸与高密度脂蛋白胆固醇比值（UHR）和周围神经传导速度（NCV）之间的相关性。
这是一项对324例T2DM患者的单中心横断面分析。所有患者被分为NCV正常组（NCVN）和NCV异常组（NCVA）。还根据本研究队列中的UHR中位数将患者分为UHR值低和高的组。对所有患者测量包括运动和感觉传导速度（分别为MCV和SCV）在内的神经生理学数据。
与UHR值低的患者相比，UHR高的组中NCVA患病率更高（P = 0.002）。即使在调整混杂因素后，UHR仍与双侧腓浅神经SCV、双侧腓总神经MCV、双侧尺神经SCV和双侧右侧正中神经MCV呈负相关。UHR被确定为与NCVA相关的危险因素，UHR每升高一个单位，NCVA患病率增加1.370倍（P < 0.001）。
这些结果表明UHR是与NCVA相关的危险因素，在T2DM患者中与NCV独立呈负相关。
