Tahmazov Elkhan, Blachier Athéna, Nabbe Patrice, Guillou-Landreat Morgane, Walter Michel, Lemey Christophe
Unité de Recherche Clinique Intersectorielle (URCI), Service hospitalo-universitaire de psychiatrie adulte, Centre Hospitalo-Universitaire (CHU) de Brest, Hôpital de Bohars, Bohars, France.
ER 7479 SPURBO, University of Western Brittany, Brest, France.
Front Psychiatry. 2024 Feb 16;15:1359764. doi: 10.3389/fpsyt.2024.1359764. eCollection 2024.
The early stages of psychotic disorders correspond to the early phases of the disease and include the prodromal phase and first-episode psychosis; they constitute a period at high risk of suicidal behaviour. A long duration of untreated psychosis (DUP) is among the risk factors of suicidal behaviour identified in this early period. Many studies have shown the effectiveness of early interventions on the overall prognosis of psychotic disorders in the early stages, and early intervention strategies have been developed and tested worldwide. Several authors reported an improvement in suicidal behaviours; however, all these data have not been systematically analysed yet. The main objective of this systematic review was to collect evidence on the effect on suicidal behaviour of early interventions for patients in the early stages of psychotic disorders.
We will carry out a systematic review of the literature according to the PRISMA criteria by searching articles in five databases (PubMed, Cochrane, PsycINFO, Scopus, EMBASE), without restriction on the publication date. The selection criteria are: articles (any type; e.g. prospective, retrospective, controlled or uncontrolled, and literature reviews) on early interventions for psychotic disorders in the early stages with data on suicide attempts, death by suicide, suicidal ideation; articles written in English or French. Exclusion criteria are: articles on suicidal behaviours in patients with psychotic disorders in the early stages, but without early intervention, and articles on early-stage psychotic disorders without data on suicidal behaviours.
If this review confirms the effectiveness on suicidal behaviours of early interventions for young patients with psychotic disorders, the development/implementation of such intervention programmes should be better promoted.
https://www.crd.york.ac.uk/prospero/, identifier CRD42021237833.
精神障碍的早期阶段对应疾病的初期，包括前驱期和首次发作精神病；它们构成了自杀行为的高风险期。未治疗精神病的持续时间较长是这一早期阶段确定的自杀行为风险因素之一。许多研究表明早期干预对精神障碍早期阶段的总体预后有效，并且早期干预策略已在全球范围内得到开发和测试。几位作者报告了自杀行为有所改善；然而，所有这些数据尚未得到系统分析。本系统评价的主要目的是收集关于精神障碍早期阶段患者早期干预对自杀行为影响的证据。
我们将根据PRISMA标准对文献进行系统评价，通过在五个数据库（PubMed、Cochrane、PsycINFO、Scopus、EMBASE）中检索文章，对发表日期无限制。选择标准为：关于精神障碍早期阶段早期干预且有自杀未遂、自杀死亡、自杀意念数据的文章（任何类型，如前瞻性、回顾性、对照或非对照以及文献综述）；用英语或法语撰写的文章。排除标准为：关于精神障碍早期阶段患者自杀行为但无早期干预的文章，以及关于精神障碍早期阶段但无自杀行为数据的文章。
如果本评价证实早期干预对患有精神障碍的年轻患者的自杀行为有效，则应更好地推广此类干预方案的开发/实施。
