Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ultrasound Obstet Gynecol. 2024 Sep;64(3):388-394. doi: 10.1002/uog.27630. Epub 2024 Jul 15.
To investigate whether immediate frozen-thawed embryo transfer (FET) in the next month following coronavirus disease 2019 (COVID-19) recovery affects ongoing pregnancy outcome.
This was a retrospective cohort study carried out at a university-affiliated reproductive medicine center. The study group (post-COVID-19 group) comprised women who were affected by COVID-19 in December 2022 and immediately underwent FET in January 2023 after recovery, with transferred embryos not exposed to the infection. The control group comprised women treated during the pre-COVID-19 period (January 2019). Multivariable logistic regression analysis and a propensity score matching (PSM) approach were used to control for potential confounders and selection bias.
A total of 200 women were included in the post-COVID-19 group and 641 women were enrolled in the control group. The rate of ongoing pregnancy was comparable between the study cohorts in both the unadjusted and confounder-adjusted logistic regression models. Other reproductive outcomes, including the odds of a positive pregnancy test, implantation, clinical pregnancy and early pregnancy loss, were similar between the comparison groups. PSM models further confirmed the lack of significant differences in pregnancy outcome between the post-COVID-19 group and the control group.
Among patients affected by COVID-19 for whom the transferred embryos were generated prior to infection, an immediate FET cycle in the next month after recovery does not seem to compromise ongoing pregnancy outcome. Thus, women who have frozen embryos from preinfection cycles should be counseled and encouraged to undergo FET as soon as possible after COVID-19 recovery. © 2024 International Society of Ultrasound in Obstetrics and Gynecology.
探讨新冠肺炎（COVID-19）康复后下一个月行即刻冻融胚胎移植（FET）是否会影响持续妊娠结局。
这是一项在大学附属医院生殖医学中心进行的回顾性队列研究。研究组（COVID-19 后组）包括 2022 年 12 月感染 COVID-19 并在康复后于 2023 年 1 月立即行 FET 的患者，移植胚胎未暴露于感染。对照组包括 COVID-19 前治疗的患者（2019 年 1 月）。采用多变量逻辑回归分析和倾向评分匹配（PSM）方法控制潜在混杂因素和选择偏倚。
COVID-19 后组共纳入 200 例患者，对照组纳入 641 例患者。在未校正和校正混杂因素的逻辑回归模型中，研究队列间的持续妊娠率相似。其他生殖结局，包括阳性妊娠试验、着床、临床妊娠和早期妊娠丢失的几率，在比较组之间相似。PSM 模型进一步证实 COVID-19 后组和对照组之间妊娠结局无显著差异。
对于感染前生成胚胎且移植胚胎未暴露于感染的 COVID-19 患者，康复后下一个月行即刻 FET 周期似乎不会影响持续妊娠结局。因此，应告知和鼓励有冷冻胚胎的女性在 COVID-19 康复后尽快行 FET。©2024 年国际妇产科超声学会。
