Infertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Infertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan, Israel.
Fertil Steril. 2022 May;117(5):974-979. doi: 10.1016/j.fertnstert.2022.01.009. Epub 2022 Jan 10.
To study the effect of patients' immunization after coronavirus disease 2019 (COVID-19) infection or messenger ribonucleic acid (mRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine on frozen-thawed embryo transfer (FET).
Cohort retrospective study.
Tertiary university affiliated medical center.
PATIENT(S): All consecutive patients undergoing FET cycles in our center. The study group (immune group) consisted of patients treated during the COVID-19 pandemic (between January 2021 and August 2021) who either recovered from COVID-19 infection or received the mRNA SARS-CoV-2 vaccine. The control groups consisted of patients treated during the COVID-19 pandemic (between January 2021 and August 2021) but were not infected or did not receive the mRNA SARS-CoV-2 vaccine (not-immune2021 group) and those treated between January 2019 and August 2019 (before the pandemic) (not-immune2019 group).
INTERVENTION(S): Frozen-thawed embryo transfer cycles.
MAIN OUTCOME MEASURE(S): Ongoing pregnancy rates and FET cycles' characteristics. Data on patient age and variables related to infertility treatment were collected from the patient records.
RESULT(S): During the study periods, 428 patients underwent 672 FET cycles. The immune group consisted of 141 patients who underwent 264 FET cycles (44 in postinfection and 220 in postvaccination), whereas the not-immune2021 and not-immune2019 groups consisted of 93 and 194 patients undergoing 125 and 283 FET cycles, respectively. Patients' characteristics and the types of endometrial preparations were comparable between the study groups. The implantation rate and clinical and ongoing pregnancy rates per transfer were similar between the study groups (immune group, postinfection and postvaccination; not-immune2021 group; not-immune2019 group).
CONCLUSION(S): Coronavirus disease 2019 infection or vaccination did not affect patients' performance or implantation in their subsequent FET cycle.
研究新型冠状病毒病（COVID-19）感染或信使核糖核酸（mRNA）严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）疫苗接种对冻融胚胎移植（FET）的影响。
队列回顾性研究。
三级大学附属医院。
在我院行 FET 周期的所有连续患者。研究组（免疫组）包括在 COVID-19 大流行期间（2021 年 1 月至 2021 年 8 月）接受治疗的患者，他们要么从 COVID-19 感染中康复，要么接种了 mRNA SARS-CoV-2 疫苗。对照组包括在 COVID-19 大流行期间（2021 年 1 月至 2021 年 8 月）接受治疗但未感染或未接种 mRNA SARS-CoV-2 疫苗的患者（2021 年非免疫组）和 2019 年 1 月至 2019 年 8 月（大流行前）接受治疗的患者（2019 年非免疫组）。
冻融胚胎移植周期。
持续妊娠率和 FET 周期特征。从患者记录中收集患者年龄和与不孕治疗相关的变量数据。
在研究期间，428 名患者进行了 672 次 FET 周期。免疫组包括 141 名患者，他们进行了 264 次 FET 周期（感染后 44 次，接种疫苗后 220 次），而非免疫 2021 组和非免疫 2019 组分别进行了 125 次和 283 次 FET 周期。研究组患者特征和子宫内膜准备类型相似。研究组之间的种植率和临床及持续妊娠率/移植相似（免疫组、感染后和接种疫苗后；非免疫 2021 组；非免疫 2019 组）。
COVID-19 感染或疫苗接种并未影响患者随后 FET 周期的表现或着床。
