Mackenzie Wearables Research Hub, Charles Perkins Centre, The University of Sydney, New South Wales, Australia.
School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, New South Wales, Australia.
Cancer Epidemiol Biomarkers Prev. 2024 Aug 1;33(8):1028-1036. doi: 10.1158/1055-9965.EPI-23-1185.
We examined the joint associations of diet and device-measured intensity-specific physical activity (PA) with all-cause mortality (ACM), cardiovascular disease (CVD), and cancer incidence.
We used data from 79,988 participants from the UK Biobank, a population-based prospective cohort study. Light PA (LPA), moderate-to-vigorous PA (MVPA), vigorous PA (VPA), and total PA (TPA) were measured using a wrist-worn accelerometer. Diet quality score (DQS) was based on 10 foods and ranged from 0 (unhealthiest) to 100 (healthiest) points. We derived joint PA and diet variables. Outcomes were ACM, CVD, and cancer incidence including PA, diet and adiposity-related (PDAR) cancer.
During a median follow-up of 8 years, 2,863 deaths occurred, 11,053 participants developed CVD, 7,005 developed cancer, and 3,400 developed PDAR cancer. Compared with the least favorable referent group (bottom PA tertile/low DQS), participants with middle and high (total and intensity specific) PA, except for LPA, had lower ACM risk and incident CVD risk, regardless of DQS. For example, among middle and high VPA and high DQS groups, CVD HR were 0.79 (95% CI, 0.74-0.86) and 0.75 (95% CI, 0.69-0.82), respectively. The pattern of cancer results was less pronounced but in agreement with the ACM and CVD incidence findings (e.g., HR, 0.90, 95% CI, 0.81-0.99; 0.88, 0.79-0.98; and 0.82, 0.74-0.92 among high VPA for low, moderate, and high DQS groups, respectively).
Device-measured PA reveals novel joint associations with diet on health outcomes.
Our results emphasize the crucial role of PA in addition to a healthy diet for reducing chronic diseases and mortality risk.
我们研究了饮食和设备测量的强度特异性体力活动（PA）与全因死亡率（ACM）、心血管疾病（CVD）和癌症发病率的联合关联。
我们使用了来自英国生物库的 79988 名参与者的数据，这是一项基于人群的前瞻性队列研究。使用腕戴式加速度计测量轻体力活动（LPA）、中高强度体力活动（MVPA）、高强度体力活动（VPA）和总体力活动（TPA）。饮食质量评分（DQS）基于 10 种食物，范围从 0（最不健康）到 100（最健康）分。我们得出了 PA 和饮食的联合变量。结局是 ACM、CVD 和癌症发病率，包括 PA、饮食和肥胖相关（PDAR）癌症。
在中位 8 年的随访期间，发生了 2863 例死亡，11053 名参与者发生 CVD，7005 名参与者发生癌症，3400 名参与者发生 PDAR 癌症。与最不利的参考组（PA 三分位最低/低 DQS）相比，除 LPA 外，中高强度（总强度和强度特异性）PA 较高的参与者的 ACM 风险和 CVD 发病风险较低，无论 DQS 如何。例如，在中高强度 VPA 和高 DQS 组中，CVD HR 分别为 0.79（95%CI，0.74-0.86）和 0.75（95%CI，0.69-0.82）。癌症结果的模式不太明显，但与 ACM 和 CVD 发病的发现一致（例如，HR，0.90，95%CI，0.81-0.99；0.88，0.79-0.98；和 0.82，0.74-0.92 分别在低、中、高 DQS 组的高 VPA 中）。
设备测量的 PA 揭示了与饮食在健康结果方面的新的联合关联。
我们的研究结果强调了 PA 除了健康饮食外，在降低慢性病和死亡率风险方面的重要作用。
