The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China; Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou 510370, China.
Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou 510370, China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510282, China.
Gen Hosp Psychiatry. 2024 Sep-Oct;90:141-149. doi: 10.1016/j.genhosppsych.2024.08.005. Epub 2024 Aug 21.
This study aimed to investigate the independent and joint associations of accelerometer-derived sleep duration and physical activity (PA) in different intensities with the risk of incident heart failure (HF).
The study included 89,572 participants (mean age 62.2 ± 7.8 years, 42.8% male) from the UK Biobank. Sleep duration (short: <6 h/day; normal: 6-8 h/day; long: >8 h/day) and PA [total PA, light PA (LPA), moderate-to-vigorous PA (MVPA), vigorous PA (VPA)] were measured using accelerometers over 7 days. MVPA and VPA were categorized according to the World Health Organization's recommended levels, while LPA and total PA were categorized based on the median. HF cases were identified through hospital records or death registries.
Over a 7-year follow-up period, 1324 participants (2.1%; incidence rate, 2.1 per 1000 person-years) developed HF. Short, but not long, sleep duration was linked to a 33% increased risk of HF [hazard ratio (HR) 1.33, 95% confidence interval (CI): 1.11-1.59]. This increased risk associated with short sleep could be mitigated by increasing PA, especially to the levels of recommended MVPA or VPA. In joint analyses, compared to participants meeting the recommended MVPA and with normal sleep duration, those not meeting the MVPA recommendation and with short sleep had the highest HF risk (HR 1.78, 95% CI: 1.42-2.25).
Accelerometer-derived short, but not long, sleep duration was associated with a higher risk of incident HF. Engaging in sufficient PA, especially recommended MVPA or VPA, can partially mitigate this risk.
本研究旨在探讨不同强度的加速计测量的睡眠时长和体力活动（PA）与心力衰竭（HF）事件风险的独立和联合关联。
本研究纳入了来自英国生物银行的 89572 名参与者（平均年龄 62.2±7.8 岁，42.8%为男性）。使用加速度计在 7 天内测量睡眠时长（短：<6 小时/天；正常：6-8 小时/天；长：>8 小时/天）和 PA [总 PA、低强度 PA（LPA）、中高强度 PA（MVPA）、高强度 PA（VPA）]。MVPA 和 VPA 根据世界卫生组织推荐的水平进行分类，而 LPA 和总 PA 则根据中位数进行分类。HF 病例通过医院记录或死亡登记确定。
在 7 年的随访期间，有 1324 名参与者（2.1%；发病率为 2.1 例/1000 人年）发生 HF。较短的睡眠时长而非较长的睡眠时长与 HF 风险增加 33%相关（风险比[HR]1.33，95%置信区间[CI]：1.11-1.59）。这种与短睡眠相关的风险可以通过增加 PA 来缓解，尤其是达到推荐的 MVPA 或 VPA 水平。在联合分析中，与符合推荐的 MVPA 和正常睡眠时长的参与者相比，不符合 MVPA 推荐且睡眠时长较短的参与者 HF 风险最高（HR 1.78，95%CI：1.42-2.25）。
加速计测量的短睡眠时长与 HF 事件风险增加相关，而较长睡眠时长则无此关联。进行足够的 PA，尤其是达到推荐的 MVPA 或 VPA，可部分缓解这种风险。
