Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; Guangdong Provincial Key Laboratory of Quality & Safety Risk Assessment for Agro-products, Guangzhou 510640, China.
Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China.
Sci Total Environ. 2024 May 1;923:171358. doi: 10.1016/j.scitotenv.2024.171358. Epub 2024 Mar 2.
Tetrabromobisphenol A (TBBPA) and Perfluorooctane sulfonate (PFOS) are emerging contaminants which coexist in marine environments, posing significant risks to ecosystems and human health. The behavior of these contaminants in the presence of dissolved organic matter (DOM), specifically the co-contamination of TBBPA and PFOS, is not well understood. The bioaccumulation, distribution, elimination, and toxic effects of TBBPA and PFOS on thick-shell mussels (Mytilus unguiculatus V.), with the absence and presence of humic acid (HA), a typical DOM, were studied. The results showed that the uptake of TBBPA decreased and the uptake of PFOS increased when exposed to 1 mg/L HA. However, at higher concentrations of HA (5 and 25 mg/L), the opposite effect was observed. Combined exposure to HA, TBBPA, and PFOS resulted in oxidative stress in the digestive gland, with the severity of stress dependent on exposure time and HA dose. Histological analysis revealed a positive correlation between HA concentration and tissue damage caused by TBBPA and PFOS. This study provides insights into the influence of HA on the bioaccumulation-elimination patterns and toxicity of TBBPA and PFOS in marine bivalves, offering valuable data for ecological and health risk assessments of combined pollutants in aquatic environments rich in DOM.
四溴双酚 A（TBBPA）和全氟辛烷磺酸（PFOS）是新兴的污染物，它们共同存在于海洋环境中，对生态系统和人类健康构成重大风险。这些污染物在溶解有机物（DOM）存在下的行为，特别是 TBBPA 和 PFOS 的共同污染，尚未得到充分理解。本研究旨在探讨厚壳贻贝（Mytilus unguiculatus V.）中 TBBPA 和 PFOS 的生物积累、分布、消除和毒性效应，以及在不存在和存在腐殖酸（HA）这种典型 DOM 的情况下的情况。结果表明，当暴露于 1mg/L HA 时，TBBPA 的摄取减少，PFOS 的摄取增加。然而，在较高浓度的 HA（5 和 25mg/L）下，观察到相反的效果。HA、TBBPA 和 PFOS 的联合暴露导致消化腺发生氧化应激，应激的严重程度取决于暴露时间和 HA 剂量。组织学分析表明，HA 浓度与 TBBPA 和 PFOS 引起的组织损伤之间存在正相关关系。本研究深入了解了 HA 对海洋双壳贝类中 TBBPA 和 PFOS 的生物积累-消除模式和毒性的影响，为富含有机物 DOM 的水生环境中联合污染物的生态和健康风险评估提供了有价值的数据。
