Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, School of Environmental Science and Engineering, Nanjing University of Information Science & Technology, 210044, Nanjing, China.
State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, 518055, Shenzhen, China.
Ecotoxicology. 2022 Jul;31(5):725-734. doi: 10.1007/s10646-022-02539-1. Epub 2022 Mar 31.
Tetrabromobisphenol A (TBBPA) is a new type of persistent organic pollutant, which causes environmental pollution and health problems, and has attracted the attention of the international research community. Once released into the environment, TBBPA can interact with dissolved organic matter (DOM), which affects its behavior. However, the effect of DOM on the biological toxicity of TBBPA remains unclear. The toxic effects of TBBPA on three model aquatic organisms (Chlorella pyrenoidosa, Daphnia magna, and Danio rerio), in the absence and presence of DOM were investigated. The order of acute toxicity of TBBPA to the three aquatic organisms was D. magna > D. rerio > C. pyrenoidosa. In the presence of DOM the median effect/lethal concentrations values of TBBPA to the three aquatic organisms decreased by at least 32 (C. pyrenoidosa), 52 (D. magna), and 6.6% (D. rerio), implying that DOM enhanced the acute toxicity of TBBPA to all the organisms. Moreover, the higher the concentration of DOM, the higher the acute toxicity of TBBPA. Furthermore, the presence of DOM increased total reactive oxygen species (ROS) induced by TBBPA in a concentration-dependent manner. A tracking analysis of total ROS in the three aquatic organisms also showed that the presence of DOM aggravated the accumulation of total ROS induced by TBBPA, indicating that oxidative stress is a characteristic mechanism of toxicity of TBBPA to aquatic organisms when DOM is present. In addition, the evaluated risk quotient indicated that the ecological risk of TBBPA to aquatic organisms can increase in environments rich in DOM.
四溴双酚 A（TBBPA）是一种新型持久性有机污染物，会造成环境污染和健康问题，已引起国际研究界的关注。一旦释放到环境中，TBBPA 就会与溶解有机物（DOM）相互作用，从而影响其行为。然而，DOM 对 TBBPA 生物毒性的影响尚不清楚。本研究在有无 DOM 的情况下，研究了 TBBPA 对三种模式水生生物（栅藻、大型溞和斑马鱼）的毒性效应。TBBPA 对三种水生生物的急性毒性顺序为大型溞>D. rerio>栅藻。在 DOM 存在的情况下，TBBPA 对三种水生生物的半数效应/致死浓度值至少降低了 32%（栅藻）、52%（大型溞）和 6.6%（D. rerio），这意味着 DOM 增强了 TBBPA 对所有生物的急性毒性。此外，DOM 浓度越高，TBBPA 的急性毒性就越高。此外，DOM 的存在以浓度依赖的方式增加了 TBBPA 诱导的总活性氧（ROS）。三种水生生物中总 ROS 的追踪分析也表明，DOM 的存在加剧了 TBBPA 诱导的总 ROS 积累，表明氧化应激是 DOM 存在时 TBBPA 对水生生物毒性的特征机制。此外，评价风险商数表明，在富含 DOM 的环境中，TBBPA 对水生生物的生态风险可能会增加。
