From the Department of Laboratory and Blood Bank (Adil, Omayma), Aseer Central Hospital; and from the Department of Clinical Laboratory Sciences (Mohammed, Sultan), Faculty of Applied Medical Sciences, King Khalid University, Abha, Kingdom of Saudi Arabia.
Saudi Med J. 2024 Mar;45(3):295-306. doi: 10.15537/smj.2024.45.3.20230776.
To determine the prevalence of leukemia in the Aseer region of Saudi Arabia and the importance of hematological, biochemical and coagulation profiles for leukemic patients in the context of disease management.
This retrospective study comprised 210 patients between 2012 and 2022 who had been diagnosed with leukemia at different ages. The multiple unpaired t-test was used to compare leukemic patients with control samples, which consisted of healthy individuals, and <0.05 was taken as significant. The data was compiled from Aseer Central Hospital in the Aseer region and collected through peripheral blood smear and bone marrow biopsy (2012-2017) or by flow cytometry (2018-2022), according to the hospital information system and registry data.
Of the total 210 leukemic patients (61.4% males and 38.6% females), 104 cases (2012-2017) were diagnosed based on peripheral blood smear and bone marrow biopsy, and 106 cases (2018-2022) based on flow cytometry. Fifteen subtypes of leukemia were identified, with chronic myeloid leukemia being the most common (34.2%), followed by acute myeloid leukemia (17.6%), chronic lymphoblastic leukemia (11.9%), and B-cell acute lymphoid leukemia (9.5%). Other rare cases were also found.
Of the 210 leukemia cases diagnosed in the Aseer region between 2012-2022, the most common subtype was chronic myeloid leukemia, followed by acute myeloid leukemia. In all leukemia subtypes, distinctive significant changes were observed in hematological parameters, biochemical parameters, and coagulation profiles.
确定沙特阿拉伯阿西尔地区白血病的流行情况，以及血液学、生化和凝血谱在疾病管理背景下对白血病患者的重要性。
本回顾性研究纳入了 2012 年至 2022 年期间在不同年龄段被诊断为白血病的 210 例患者。采用多组独立样本 t 检验比较白血病患者与对照组（健康个体）的差异，以 P<0.05 为差异有统计学意义。数据来源于阿西尔地区阿西尔中央医院，通过外周血涂片和骨髓活检（2012-2017 年）或流式细胞术（2018-2022 年）收集，依据医院信息系统和登记数据。
在 210 例白血病患者中（男性占 61.4%，女性占 38.6%），104 例（2012-2017 年）根据外周血涂片和骨髓活检诊断，106 例（2018-2022 年）根据流式细胞术诊断。共鉴定出 15 种白血病亚型，其中慢性髓系白血病最为常见（34.2%），其次为急性髓系白血病（17.6%）、慢性淋巴细胞白血病（11.9%）和 B 细胞急性淋巴细胞白血病（9.5%）。还发现了其他罕见病例。
在 2012-2022 年期间，阿西尔地区诊断出的 210 例白血病病例中，最常见的亚型是慢性髓系白血病，其次是急性髓系白血病。在所有白血病亚型中，均观察到血液学参数、生化参数和凝血谱的显著变化。
