School of Rehabilitation Medicine, Shandong Second Medical University, Weifang, China.
Shanghai University of Medicine & Health Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
BMC Geriatr. 2024 Mar 4;24(1):220. doi: 10.1186/s12877-024-04765-0.
To analyse and discuss the association of gender differences with the risk and incidence of poststroke aphasia (PSA) and its types, and to provide evidence-based guidance for the prevention and treatment of poststroke aphasia in clinical practice.
Embase, PubMed, Cochrane Library and Web of Science were searched from January 1, 2002, to December 1, 2023.
Including the total number of strokes, aphasia, the number of different sexes or the number of PSA corresponding to different sex.
Studies with missing data, aphasia caused by nonstroke and noncompliance with the requirements of literature types were excluded.
36 papers were included, from 19 countries. The analysis of 168,259 patients with stroke and 31,058 patients with PSA showed that the risk of PSA was 1.23 times higher in female than in male (OR = 1.23, 95% CI = 1.19-1.29, P < 0.001), with a prevalence of PSA of 31% in men and 36% in women, and an overall prevalence of 34% (P < 0.001). Analysis of the risk of the different types of aphasia in 1,048 patients with PSA showed a high risk in females for global, broca and Wenicke aphasia, and a high risk in males for anomic, conductive and transcortical aphasia, which was not statistically significant by meta-analysis. The incidence of global aphasia (males vs. females, 29% vs. 32%) and broca aphasia (17% vs 19%) were higher in females, and anomic aphasia (19% vs 14%) was higher in males, which was statistically significant (P < 0.05).
There are gender differences in the incidence and types of PSA. The risk of PSA in female is higher than that in male.
分析和讨论性别差异与卒中后失语症（PSA）风险和发生率及其类型的关系，为临床实践中 PSA 的防治提供循证指导。
检索 2002 年 1 月 1 日至 2023 年 12 月 1 日的 Embase、PubMed、Cochrane 图书馆和 Web of Science。
包括总卒中人数、失语症人数、不同性别人数或不同性别 PSA 对应人数。
排除数据缺失、非卒中引起的失语症和不符合文献类型要求的研究。
纳入 36 篇来自 19 个国家的研究。对 168259 例卒中患者和 31058 例 PSA 患者的分析表明，女性 PSA 风险比男性高 1.23 倍（OR=1.23，95%CI=1.19-1.29，P<0.001），男性 PSA 患病率为 31%，女性为 36%，总体患病率为 34%（P<0.001）。对 1048 例 PSA 患者不同类型失语症风险的分析显示，女性全球、布罗卡和 Wernicke 失语症风险较高，男性命名性、传导性和皮质下失语症风险较高，但荟萃分析未显示统计学意义。全球性失语症（男性 vs 女性，29% vs 32%）和布罗卡失语症（17% vs 19%）在女性中发生率较高，命名性失语症（19% vs 14%）在男性中发生率较高，差异有统计学意义（P<0.05）。
PSA 的发生率和类型存在性别差异，女性 PSA 风险高于男性。
