Kinney A B, Blount M
Nurs Res. 1979 Sep-Oct;28(5):287-90.
Twenty-one female and 19 male subjects who had normal physical and laboratory examinations were randomly assigned into four groups of 10 subjects each. Each group was then randomly assigned a number (150, 180, 210, 240) which determined the amount of cranberry juice, in milliliters, members of that group would ingest with each meal during the experimental phase of the study. The study took place over a 12-day period. A one-group before-and-after design was used, with each subject serving as his or her own control. Diet was controlled; menus on days 1 through 6 were repeated on days 7 through 12 with the addition of cranberry juice at each meal. Subjects used nitrazine pH tape to measure the pH of midstream urine at each voiding. There were significant (.01 level) differences in mean urinary pH between each control group and its corresponding experimental group. Anticipated problems with increased number of bowel movements, weight gain, increased voiding frequency, and subject pH measurement inaccuracy did not occur.
21名身体检查和实验室检查结果均正常的女性受试者和19名男性受试者被随机分为四组，每组10人。然后给每组随机分配一个数字（150、180、210、240），该数字决定了在研究的实验阶段该组成员每餐摄入蔓越莓汁的毫升数。研究持续了12天。采用单组前后设计，每个受试者作为自己的对照。饮食受到控制；第1天至第6天的菜单在第7天至第12天重复，每餐增加蔓越莓汁。受试者在每次排尿时使用硝嗪pH试纸测量中段尿的pH值。每个对照组与其相应的实验组之间的平均尿pH值存在显著（0.01水平）差异。预期的排便次数增加、体重增加、排尿频率增加以及受试者pH值测量不准确等问题并未出现。
