Valentova Katerina, Stejskal David, Bednar Petr, Vostalova Jitka, Cíhalík Cestmír, Vecerova Renata, Koukalova Dagmar, Kolar Milan, Reichenbach Richard, Sknouril Lucyna, Ulrichova Jitka, Simanek Vilím
Departments of Medical Chemistry and Biochemistry and Microbiology, Faculty of Medicine and Dentistry, Palacký University, HnevotínskA 3, CZ-77515 Olomouc, Czech Republic.
J Agric Food Chem. 2007 Apr 18;55(8):3217-24. doi: 10.1021/jf0636014. Epub 2007 Mar 24.
This study assessed the effect of an 8 week consumption of dried cranberry juice (DCJ) on 65 healthy young women. Basic biochemical and hematological parameters, antioxidant status, presence of metabolites in urine, and urine ex vivo antiadherence activity were determined throughout the trial. A 400 mg amount of DCJ/day had no influence on any parameter tested. A 1200 mg amount of DCJ/day resulted in a statistically significant decrease in serum levels of advanced oxidation protein products. This specific protective effect against oxidative damage of proteins is described here for the first time. Urine samples had an inhibitory effect on the adhesion of uropathogenic Escherichia coli strains, but no increase in urine acidity was noted. Hippuric acid, isomers of salicyluric and dihydroxybenzoic acids, and quercetin glucuronide were identified as the main metabolites. In conclusion, cranberry fruits are effective not only in the prevention of urinary tract infection but also for the prevention of oxidative stress.
本研究评估了65名健康年轻女性连续8周饮用蔓越莓汁（DCJ）的效果。在整个试验过程中，测定了基本生化和血液学参数、抗氧化状态、尿液中代谢产物的存在以及尿液体外抗黏附活性。每天400毫克的DCJ对任何测试参数均无影响。每天1200毫克的DCJ导致血清晚期氧化蛋白产物水平出现统计学上的显著下降。这种针对蛋白质氧化损伤的特异性保护作用在此首次被描述。尿液样本对尿路致病性大肠杆菌菌株的黏附具有抑制作用，但未观察到尿液酸度增加。马尿酸、水杨尿酸和二羟基苯甲酸的异构体以及槲皮素葡萄糖醛酸苷被确定为主要代谢产物。总之，蔓越莓果实不仅对预防尿路感染有效，而且对预防氧化应激也有效。
