Gupta Nainsi, Ahmed Aftab, Galib Rubina, Raza Adil
Department of Otorhinolaryngology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, 202002 Uttar Pradesh India.
Department of Microbiology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, 202002 Uttar Pradesh India.
Indian J Otolaryngol Head Neck Surg. 2024 Feb;76(1):658-663. doi: 10.1007/s12070-023-04242-x. Epub 2023 Oct 6.
The study was conducted on 100 patients in the Department of ENT and Microbiology from December 2020-2022. Patients above the age of 12 years were evaluated. Those who received antibiotics in the last 12 months. and age < 12 years were excluded. Patients were subjected to a detailed history, clinical and radiological examination. After the informed consent of patients and ethical cleareance, samples were taken from the middle meatus area and studied for antibiotics sensitivity: levofloxacin, vancomycin, amikacin, amoxicillin-clavulanic acid and azithromycin.
The study was male predominance (71%), with the maximum of patients in the age group 21-30 years (38%). The most common clinical features were nasal obstruction ( 96%) and mucopurulent discharge (100%). The most common isolate was (45.16%). In Gram-positive, the maximum resistance was shown to azithromycin and amoxicillin-clavulanic acid and the maximum sensitivity to vancomycin, levofloxacin and amikacin.
Antibiotic resistance seems to be emerging for azithromycin and amoxicillin-clavulanic acid at a higher rate. ( 19.35%) maintains a significant presence with associated increased levels of antibiotic resistance.
该研究于2020年12月至2022年在耳鼻喉科和微生物科对100例患者进行。对12岁以上的患者进行评估。排除过去12个月内接受过抗生素治疗且年龄<12岁的患者。对患者进行详细的病史、临床和放射学检查。在获得患者知情同意并通过伦理审查后，从中鼻道区域采集样本，研究其对左氧氟沙星、万古霉素、阿米卡星、阿莫西林-克拉维酸和阿奇霉素的抗生素敏感性。
该研究男性占主导（71%），年龄组21 - 30岁的患者最多（38%）。最常见的临床特征是鼻塞（96%）和黏液脓性分泌物（100%）。最常见的分离菌是[此处原文缺失具体菌名]（45.16%）。在革兰氏阳性菌中，对阿奇霉素和阿莫西林-克拉维酸的耐药性最高，对万古霉素、左氧氟沙星和阿米卡星的敏感性最高。
阿奇霉素和阿莫西林-克拉维酸的抗生素耐药性似乎正在以较高的速率出现。[此处原文缺失具体菌名]（19.35%）存在显著比例且抗生素耐药水平有所增加。
