Nagano Hiromi, Matsumoto Hayato, Miyamoto Yumi, Takumi Koji, Nakajo Masatoyo, Yamashita Masaru
Department of Otolaryngology Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520 Japan.
Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520 Japan.
Indian J Otolaryngol Head Neck Surg. 2024 Feb;76(1):1264-1271. doi: 10.1007/s12070-023-04258-3. Epub 2023 Oct 13.
Adult T-cell leukemia/lymphoma (ATL) is a form of leukemia caused by the human T-cell leukemia virus type I (HTLV-1). Otolaryngologists often diagnose ATL based on cervical lymphadenopathy or Waldeyer ring lesions. However, there are few reports of ATL occurring in the nasal and paranasal cavity. Here, we report four such cases of ATL. Case 1: An 82-year-old man diagnosed with acute-type ATL with a tumor in the nasal cavity underwent 5 courses of THP-COP, but died after 36 months due to ATL. Case 2: A 62-year-old woman diagnosed with lymphoma-type ATL with a tumor in the frontal sinus was treated with 5 courses of VCAP-AMP-VECP, and has survived for more than 10 years. Case 3: A 64-year-old man diagnosed with lymphoma-type ATL with a tumor in the maxillary sinus underwent 8 courses of VCAP-AMP-VECP and 2 courses of mogamulizumab, but died after 34 months due to ATL. Case 4: A 52-year-old woman diagnosed with lymphoma-type ATL with tumors in both ethmoid sinuses received 2 courses of CHOP, 2 courses of DeVIC, radiotherapy (32 Gy) and 2 courses of mogamulizumab, but died after 9 months due to ATL.
成人T细胞白血病/淋巴瘤（ATL）是一种由I型人类T细胞白血病病毒（HTLV-1）引起的白血病。耳鼻喉科医生常根据颈部淋巴结肿大或瓦尔代尔环病变来诊断ATL。然而，鼻腔和鼻窦发生ATL的报道较少。在此，我们报告4例此类ATL病例。病例1：一名82岁男性被诊断为急性型ATL，鼻腔有肿瘤，接受了5个疗程的THP-COP治疗，但36个月后因ATL死亡。病例2：一名62岁女性被诊断为淋巴瘤型ATL，额窦有肿瘤，接受了5个疗程的VCAP-AMP-VECP治疗，已存活超过10年。病例3：一名64岁男性被诊断为淋巴瘤型ATL，上颌窦有肿瘤，接受了8个疗程的VCAP-AMP-VECP和2个疗程的莫加莫拉单抗治疗，但34个月后因ATL死亡。病例4：一名52岁女性被诊断为淋巴瘤型ATL，筛窦有肿瘤，接受了2个疗程的CHOP、2个疗程的DeVIC、放疗（32 Gy）和2个疗程的莫加莫拉单抗治疗，但9个月后因ATL死亡。
