Katami Akinobu, Inoue Takamitsu, Sakurai Hiromichi, Onozawa Mizuki, Hisasue Shin-Ichi, Kawai Koji, Miyazaki Jun
Department of Renal and Urological Surgery International University of Health and Welfare Narita Hospital Narita Chiba Japan.
IJU Case Rep. 2024 Feb 2;7(2):185-187. doi: 10.1002/iju5.12700. eCollection 2024 Mar.
Contracted bladder is a rare adverse effect of intravesical Bacillus Calmette-Guérin instillation, with an incidence of 0.2-3.3%. This report aimed to present a case of contracted bladder successfully treated with a low-dose oral steroid.
A 78-year-old man underwent a third transurethral resection of a bladder tumor. The pathological diagnosis was urothelial carcinoma in situ. After the fifth instillation of the second-line induction therapy of Bacillus Calmette-Guérin, the patient discontinued treatment because of increased urinary frequency and a continuous mean voiding volume of 80 mL. The patient was diagnosed with a contracted bladder based on computed tomography findings and a urination chart. After initiating oral prednisolone (20 mg/day), the patient experienced significant recovery within 2 weeks for both urinary frequency and mean voiding volume of 226 mL.
A patient with a contracted bladder after Bacillus Calmette-Guérin instillation was successfully treated with low-dose oral steroid therapy.
膀胱挛缩是膀胱内灌注卡介苗罕见的不良反应，发生率为0.2%-3.3%。本报告旨在介绍一例通过低剂量口服类固醇成功治疗膀胱挛缩的病例。
一名78岁男性接受了第三次经尿道膀胱肿瘤切除术。病理诊断为原位尿路上皮癌。在卡介苗二线诱导治疗的第五次灌注后，患者因尿频增加和平均排尿量持续为80毫升而停止治疗。根据计算机断层扫描结果和排尿图表，该患者被诊断为膀胱挛缩。开始口服泼尼松龙（20毫克/天）后，患者在2周内尿频和平均排尿量226毫升均有显著恢复。
卡介苗灌注后发生膀胱挛缩的患者通过低剂量口服类固醇治疗获得成功。
