Morozumi Kento, Namiki Shunichi, Kudo Takashi, Aizawa Masataka, Ioritani Naomasa, Sakamoto Kazuhiro, Nakamura Yasuhiro
Department of Urology, Japan Community Health Care Organization Sendai Hospital, Sendai, Japan.
Department of Pathology, Osaki Citizen Hospital, Osaki, Japan.
Case Rep Oncol. 2016 Nov 24;9(3):786-791. doi: 10.1159/000452945. eCollection 2016 Sep-Dec.
A 73-year-old male underwent transurethral resection of a bladder tumor in August 2010 and April 2011. Pathological examination revealed urothelial carcinoma. After the surgery, chemotherapy and intravesical Bacillus Calmette-Guerin instillation were performed. In September 2014, he once again underwent transurethral resection of the bladder tumor for recurrence, and was again diagnosed with urothelial carcinoma, pT2, by pathological examination. After neoadjuvant chemotherapy, radical cystectomy for tumor recurrence was performed. Pathological examination at this time revealed small cell carcinoma, pT3N0. It is rare for urothelial carcinoma to change to small cell carcinoma, and the mechanism and cause of this change are still unknown. In this case report, we discuss what causes small cell carcinoma of the urinary bladder and review the literature regarding its origin.
一名73岁男性于2010年8月和2011年4月接受了经尿道膀胱肿瘤切除术。病理检查显示为尿路上皮癌。手术后，进行了化疗和膀胱内卡介苗灌注。2014年9月，他因肿瘤复发再次接受经尿道膀胱肿瘤切除术，病理检查再次诊断为尿路上皮癌，pT2。新辅助化疗后，因肿瘤复发进行了根治性膀胱切除术。此时的病理检查显示为小细胞癌，pT3N0。尿路上皮癌转变为小细胞癌的情况罕见，这种转变的机制和原因尚不清楚。在本病例报告中，我们讨论了膀胱小细胞癌的病因，并回顾了有关其起源的文献。
