Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Front Immunol. 2024 Feb 19;15:1341180. doi: 10.3389/fimmu.2024.1341180. eCollection 2024.
Mucosal-associated invariant T (MAIT) cells are a unique subset of T cells that recognizes metabolites derived from the vitamin B2 biosynthetic pathway. Since the identification of cognate antigens for MAIT cells, knowledge of the functions of MAIT cells in cancer, autoimmunity, and infectious diseases has been rapidly expanding. Recently, MAIT cells have been found to contribute to visual protection against autoimmunity in the eye. The protective functions of MAIT cells are induced by T-cell receptor (TCR)-mediated activation. However, the underlying mechanisms remain unclear. Thus, this mini-review aims to discuss our findings and the complexity of MAIT cell-mediated immune regulation in the eye.
黏膜相关恒定 T（MAIT）细胞是 T 细胞的一个独特亚群，可识别来自维生素 B2 生物合成途径的代谢物。自从鉴定了 MAIT 细胞的同源抗原以来，MAIT 细胞在癌症、自身免疫和传染病中的功能知识迅速扩展。最近，发现 MAIT 细胞有助于防止眼睛自身免疫中的视觉损伤。MAIT 细胞的保护功能是由 T 细胞受体（TCR）介导的激活诱导的。然而，其潜在机制尚不清楚。因此，本篇综述旨在讨论我们在眼睛中发现的 MAIT 细胞介导的免疫调节的复杂性。
