Department of Biochemistry, Jawahar Lal Nehru Medical College, Aligarh Muslim University, Aligarh, India.
Department of Biochemistry, King George Medical University, Lucknow, India.
IUBMB Life. 2024 Aug;76(8):468-484. doi: 10.1002/iub.2814. Epub 2024 Mar 5.
Nanotechnology is considered a successful approach for cancer diagnosis and treatment. Preferentially, cancer cell recognition and drug targeting via nano-delivery system include the penetration of anticancer agents into the cell membrane to damage the cancer cell by protein modification, DNA oxidation, or mitochondrial dysfunction. The past research on nano-delivery systems and their target has proven the beneficial achievement in a malignant tumor. Modern perceptions using inventive nanomaterials for cancer management have been offered by a multifunctional platform based on various nano-carriers with the probability of imaging and cancer therapy simultaneously. Emerging nano-delivery systems in cancer therapy still lack knowledge of the biological functions behind the interaction between nanoparticles and cancer cells. Since the potential of engineered nanoparticles addresses the various challenges, limiting the success of cancer therapy subsequently, it is a must to review the molecular targeting of a nano-delivery system to enhance the therapeutic efficacy of cancer. This review focuses on using a nano-delivery system, an imaging system, and encapsulated nanoparticles for cancer therapy.
纳米技术被认为是癌症诊断和治疗的一种成功方法。通过纳米递药系统进行癌细胞识别和药物靶向,优选地包括将抗癌剂穿透细胞膜,通过蛋白质修饰、DNA 氧化或线粒体功能障碍来破坏癌细胞。过去对纳米递药系统及其靶标的研究已经证明了在恶性肿瘤中取得了有益的成果。基于各种纳米载体的多功能平台为癌症管理提供了现代观念,具有同时成像和癌症治疗的可能性。新兴的癌症治疗纳米递药系统仍然缺乏对纳米颗粒与癌细胞相互作用背后的生物学功能的了解。由于工程纳米颗粒的潜力解决了各种挑战,随后限制了癌症治疗的成功,因此必须审查纳米递药系统的分子靶向,以提高癌症的治疗效果。本综述重点介绍了使用纳米递药系统、成像系统和封装纳米颗粒进行癌症治疗。