Shaikh Rehanoddin, Bhattacharya Sankha
Department of Pharmaceutics, School of Pharmacy & Technology Management, SVKM'S NMIMS Deemed-to-be University, Shirpur, Maharashtra, 425405, India.
Curr Med Chem. 2024 Aug 1. doi: 10.2174/0109298673306752240726104241.
Polymeric micelles are becoming the method of choice for a nano-drug delivery system, especially in colorectal cancer treatment. These tiny structures have become popular for their amazing qualities that make drug delivery more efficient and therapies better. Colorectal cancer, also known as colon cancer, is one of the most common and deadly cancers in the world. Traditional chemotherapy is good, but it has big downsides, like harming other parts of the body and making people sick all over. Polymeric micelles give a new way to fix these problems by being easier on the body, breaking down naturally, and staying in the blood longer. The polymeric micelles, which are loaded with drugs, are sheltered within the tumor, which leads to a reduction in off-site effects and an increase in the targeting and accumulation of chemotherapeutics at the cancer site. This review paper elaborates on the current status of polymeric micelles as a method for nano-drug delivery for chemotherapy, emphasizing their efficacy in managing cancer. The paper also talks about the various types of copolymers that are used to create polymeric micelles, the different types of micelles, their physicochemical properties, the preparation process, characterization, and their application in cancer diagnostics.
聚合物胶束正成为纳米药物递送系统的首选方法，尤其是在结直肠癌治疗方面。这些微小的结构因其惊人的特性而受到欢迎，这些特性使药物递送更高效，治疗效果更好。结直肠癌，也称为结肠癌，是世界上最常见且致命的癌症之一。传统化疗效果不错，但有很大的缺点，比如会损害身体的其他部位，使人全身不适。聚合物胶束提供了一种新方法来解决这些问题，因为它们对身体的刺激性较小，能自然分解，并且在血液中停留的时间更长。载有药物的聚合物胶束会聚集在肿瘤内部，这会减少副作用，并增加化疗药物在癌症部位的靶向性和聚集量。这篇综述文章阐述了聚合物胶束作为化疗纳米药物递送方法的现状，强调了它们在癌症治疗中的功效。文章还讨论了用于制备聚合物胶束的各种共聚物类型、不同类型的胶束、它们的物理化学性质、制备过程、表征以及它们在癌症诊断中的应用。
