Department of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan Province, China.
Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Cell Mol Neurobiol. 2024 Mar 6;44(1):27. doi: 10.1007/s10571-024-01458-5.
Epilepsy, a prevalent neurological disorder characterized by high morbidity, frequent recurrence, and potential drug resistance, profoundly affects millions of people globally. Understanding the microscopic mechanisms underlying seizures is crucial for effective epilepsy treatment, and a thorough understanding of the intricate neural circuits underlying epilepsy is vital for the development of targeted therapies and the enhancement of clinical outcomes. This review begins with an exploration of the historical evolution of techniques used in studying neural circuits related to epilepsy. It then provides an extensive overview of diverse techniques employed in this domain, discussing their fundamental principles, strengths, limitations, as well as their application. Additionally, the synthesis of multiple techniques to unveil the complexity of neural circuits is summarized. Finally, this review also presents targeted drug therapies associated with epileptic neural circuits. By providing a critical assessment of methodologies used in the study of epileptic neural circuits, this review seeks to enhance the understanding of these techniques, stimulate innovative approaches for unraveling epilepsy's complexities, and ultimately facilitate improved treatment and clinical translation for epilepsy.
癫痫是一种常见的神经障碍疾病，其发病率高、复发频繁且可能存在药物抗性，对全球数百万人产生了深远影响。深入了解癫痫发作的微观机制对于有效的癫痫治疗至关重要，而深入了解癫痫相关神经回路的复杂结构对于靶向治疗的发展和临床疗效的提高至关重要。本综述首先探讨了研究与癫痫相关的神经回路的技术的历史演变。然后，它广泛概述了该领域使用的多种技术，讨论了它们的基本原理、优势、局限性以及应用。此外，还总结了综合多种技术以揭示神经回路复杂性的方法。最后，本综述还介绍了与癫痫神经回路相关的靶向药物治疗。通过对癫痫神经回路研究中使用的方法进行批判性评估，本综述旨在增强对这些技术的理解，激发创新方法以揭示癫痫的复杂性，并最终促进改善癫痫的治疗和临床转化。
