Department of Life Science, Institute of Environmental Medicine for Green Chemistry, Dongguk University Biomedi Campus, Gyeonggi-do, Republic of Korea.
Research and Innovation Center, Amorepacific, Gyeonggi-do, Republic of Korea.
Front Public Health. 2024 Feb 20;12:1328089. doi: 10.3389/fpubh.2024.1328089. eCollection 2024.
Ultraviolet B (UVB) from sunlight represents a major environmental factor that causes toxic effects resulting in structural and functional cutaneous abnormalities in most living organisms. Although numerous studies have indicated the biological mechanisms linking UVB exposure and cutaneous manifestations, they have typically originated from a single study performed under limited conditions.
We accessed all publicly accessible expression data of various skin cell types exposed to UVB, including skin biopsies, keratinocytes, and fibroblasts. We performed biological network analysis to identify the molecular mechanisms and identify genetic biomarkers.
We interpreted the inflammatory response and carcinogenesis as major UVB-induced signaling alternations and identified three candidate biomarkers (, , and ). Moreover, we confirmed that these three biomarkers contribute to the survival probability of patients with cutaneous melanoma, the most aggressive and lethal form of skin cancer.
Our findings will aid the understanding of UVB-induced cutaneous toxicity and the accompanying molecular mechanisms. In addition, the three candidate biomarkers that change molecular signals due to UVB exposure of skin might be related to the survival rate of patients with cutaneous melanoma.
阳光中的紫外线 B（UVB）是导致大多数生物出现结构和功能皮肤异常的主要环境因素，具有毒性作用。虽然许多研究表明了紫外线 B 暴露与皮肤表现之间的生物学机制，但这些研究通常来自于在有限条件下进行的单一研究。
我们获取了所有可公开访问的各种皮肤细胞类型暴露于 UVB 的表达数据，包括皮肤活检、角质形成细胞和成纤维细胞。我们进行了生物网络分析，以确定分子机制并识别遗传生物标志物。
我们将炎症反应和癌变解释为主要的 UVB 诱导信号改变，并鉴定出三个候选生物标志物（、和）。此外，我们还证实这三个生物标志物与皮肤黑色素瘤患者的生存概率有关，皮肤黑色素瘤是最具侵袭性和致命性的皮肤癌。
我们的研究结果将有助于理解 UVB 诱导的皮肤毒性及其伴随的分子机制。此外，由于皮肤暴露于 UVB 而改变分子信号的三个候选生物标志物可能与皮肤黑色素瘤患者的生存率有关。
