Girme Amit, Gupta Vernika
General Surgery, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Pune, IND.
Cureus. 2024 Feb 4;16(2):e53574. doi: 10.7759/cureus.53574. eCollection 2024 Feb.
Polycystic kidney disease (PKD) is a genetic disorder that comprises multiple cystic lesions in the kidneys. The association of PKD with gastric cancer has been studied. We present a rare presentation of stomach cancer with polycystic liver and kidney disease. A male patient in his 40s presented with epigastric pain, nausea, retrosternal burning, and occasional episodes of vomiting. Esophagogastroduodenoscopy revealed ulceroproliferative growth in the prepyloric region. Biopsies revealed moderately differentiated adenocarcinoma which was confirmed by contrast-enhanced computed tomography of the abdomen and pelvis. This showed a chance finding of polycystic kidney and liver disease. After confirmation with a positron emission tomography scan, the patient was diagnosed with gastric carcinoma (cT3N1M0, Stage IIB) with polycystic kidney and liver disease. We provide a case of early-stage stomach cancer in a patient with PKD. More extensive research is needed for a better understanding of this association between polycystic kidney and liver disease and gastric cancer development, to achieve earlier diagnosis.
多囊肾病（PKD）是一种遗传性疾病，其特征为肾脏出现多个囊性病变。PKD与胃癌之间的关联已得到研究。我们报告了一例罕见的同时患有多囊肝和多囊肾病的胃癌病例。一名40多岁的男性患者出现上腹部疼痛、恶心、胸骨后烧灼感及偶尔呕吐症状。食管胃十二指肠镜检查显示幽门前区有溃疡增殖性肿物。活检显示为中分化腺癌，腹部和盆腔增强计算机断层扫描证实了这一诊断。扫描偶然发现了多囊肝和多囊肾病。经正电子发射断层扫描确认后，该患者被诊断为患有多囊肝和多囊肾病的胃癌（cT3N1M0，IIB期）。我们提供了一例患有PKD的早期胃癌病例。需要进行更广泛的研究，以更好地理解多囊肝和多囊肾病与胃癌发生之间的这种关联，从而实现早期诊断。
