Lacy Brian E, Delfini Régis, Fladung Bernward, Lange Robert
Division of Gastroenterology, Mayo Clinic, Jacksonville, FL, USA.
Sanofi, Frankfurt, Germany.
Therap Adv Gastroenterol. 2024 Mar 4;17:17562848241232605. doi: 10.1177/17562848241232605. eCollection 2024.
Constipation is characterized by symptoms of straining, hard stool, difficult evacuation, and infrequent bowel movements. Online surveys provide valuable information about patients' perspectives, symptoms, management, treatment satisfaction, and risk factors.
This survey explored subject experiences involving 20 gastrointestinal (GI) conditions. In total, 20,099 respondents in seven countries with varied cultural and socioeconomic backgrounds participated. analysis of 'self-reported constipation' and related symptoms experienced within the past 6 months and the last episode of constipation provided data on prevalence, demographics, frequency and duration of episodes and related symptoms, impact on quality of life (QoL), management with or without laxatives, and resulting treatment satisfaction.
In total, 10,425 subjects reported constipation within 6 months and 2637 at the last episode. Prevalence was highest in females and younger adults. Most subjects reported various coexisting GI symptoms. Almost 80% of 6865 episodes reported by 5337 subjects occurred every 2-3 months to every 2-3 weeks. A higher frequency of constipation correlated with a greater impact on QoL. On a 10-point scale, the mean impact was 6.4. More than 90% of respondents had episodes ranging from 1 day to 1 week. More than 90% took action; 16% used laxatives, of whom 80.3% were satisfied.
Constipation, a highly prevalent disorder, spans cultures and socioeconomic classes. Its chronic recurrence has a significant impact on QoL, resulting in symptom self-management in >90% of subjects. Significantly higher satisfaction rates in subjects treated with than without laxatives reflect subjects' reports that self-reported constipation can be treated effectively with laxatives.
便秘的特征是伴有用力排便、大便干结、排便困难和排便次数减少等症状。在线调查能提供有关患者观点、症状、管理、治疗满意度及风险因素的宝贵信息。
本调查探讨了涉及20种胃肠道疾病的受试者经历。共有来自七个国家、具有不同文化和社会经济背景的20099名受访者参与。对过去6个月内自我报告的“便秘”及相关症状以及最近一次便秘发作的分析提供了有关患病率、人口统计学特征、发作频率和持续时间以及相关症状、对生活质量（QoL）的影响、使用或未使用泻药的管理情况以及由此产生的治疗满意度的数据。
共有10425名受试者报告在6个月内出现便秘，2637名受试者报告了最近一次便秘发作。患病率在女性和年轻人中最高。大多数受试者报告了各种并存的胃肠道症状。5337名受试者报告的6865次发作中，近80%发生在每2 - 3个月至每2 - 3周。便秘频率越高，对生活质量的影响越大。在10分制量表上，平均影响为6.4分。超过90%的受访者发作持续时间为1天至1周。超过90%的受访者采取了行动；16%的人使用了泻药，其中80.3%的人感到满意。
便秘是一种高度普遍的疾病，跨越不同文化和社会经济阶层。其慢性复发对生活质量有重大影响，导致超过90%的受试者进行症状自我管理。使用泻药治疗的受试者满意度显著高于未使用泻药的受试者，这反映了受试者的报告，即自我报告的便秘可用泻药有效治疗。
