Response to first-line pembrolizumab in metastatic -mutated non-small-cell lung cancer.

This retrospective study aims to identify a possible predictive role of mutations in non-small-cell lung cancer in response to first-line pembrolizumab, either as monotherapy or combined with chemotherapy. Patients received pembrolizumab alone (n = 213) or associated with chemotherapy (n = 81). A mutation in the gene was detected in 27% of patients. In patients on pembrolizumab alone, median progression-free survival in -mutated cases was longer than in wild-type cases (11.3 vs 4.4 months; p = 0.019), whereas median overall survival did not reach statistical significance (22.1 vs 12.5 months; p = 0.119). Patients receiving chemo-immunotherapy with -positive tumors had a similar progression-free survival (9.7 vs 7.3 months; p = 0.435); overall survival data were immature. This study suggests a correlation between status and response to pembrolizumab.