Boston University Alzheimer's Disease Research Center, BU CTE Center, Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
J Neurotrauma. 2024 Jun;41(11-12):1399-1408. doi: 10.1089/neu.2023.0391. Epub 2024 Apr 15.
Repetitive head impacts (RHIs) from football are associated with the neurodegenerative tauopathy chronic traumatic encephalopathy (CTE). It is unclear whether a history of traumatic brain injury (TBI) is sufficient to precipitate CTE neuropathology. We examined the association between TBI and CTE neuropathology in 580 deceased individuals exposed to RHIs from football. TBI history was assessed using a modified version of the Ohio State University TBI Identification Method Short Form administered to informants. There were 22 donors who had no TBI, 213 who had at least one TBI without loss of consciousness (LOC), 345 who had TBI with LOC, and, of those with a history of TBI with LOC, 36 who had at least one moderate-to-severe TBI (msTBI, LOC >30 min). CTE neuropathology was diagnosed in 405. There was no association between CTE neuropathology status or severity and TBI with LOC (odds ratio [OR] = 0.95, 95% confidence interval [CI] = 0.64-1.41; OR = 1.22, 95% CI = 0.71-2.09) or msTBI (OR = 0.70, 95% CI = 0.33-1.50; OR = 1.01, 95% CI = 0.30-3.41). There were no associations with other neurodegenerative or cerebrovascular pathologies examined. TBI with LOC and msTBI were not associated with CTE neuropathology in this sample of brain donors exposed to RHIs from American football.
重复性头部撞击（RHIs）与神经退行性tau 病慢性创伤性脑病（CTE）有关。目前尚不清楚创伤性脑损伤（TBI）病史是否足以引发 CTE 神经病理学。我们研究了 580 名暴露于美式橄榄球 RHIs 的已故个体中 TBI 与 CTE 神经病理学之间的关联。TBI 病史通过向知情人提供的俄亥俄州立大学 TBI 识别方法简化版进行评估。有 22 名捐赠者没有 TBI，213 名捐赠者至少有一次 TBI 但无意识丧失（LOC），345 名捐赠者有 TBI 伴有 LOC，在有 TBI 伴有 LOC 病史的患者中，有 36 名至少有一次中度至重度 TBI（msTBI，LOC >30 分钟）。405 名患者诊断为 CTE 神经病理学。CTE 神经病理学状态或严重程度与 TBI 伴有 LOC（比值比 [OR] = 0.95，95%置信区间 [CI] = 0.64-1.41；OR = 1.22，95% CI = 0.71-2.09）或 msTBI（OR = 0.70，95% CI = 0.33-1.50；OR = 1.01，95% CI = 0.30-3.41）之间没有关联。也与其他神经退行性或脑血管病变无关。在接触美式橄榄球 RHIs 的脑捐赠者样本中，TBI 伴有 LOC 和 msTBI 与 CTE 神经病理学没有关联。
