Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (BHU), Varanasi, Uttar Pradesh, 221005, India.
Nanomedicine (Lond). 2024 Mar;19(7):633-651. doi: 10.2217/nnm-2023-0302. Epub 2024 Mar 6.
Nanomedicine has opened up new avenues for cancer treatment by enhancing drug solubility, permeability and targeted delivery to cancer cells. Despite its numerous advantages over conventional therapies, nanomedicine may exhibit off-target drug distribution, harming nontarget regions. The increased permeation and retention effect of nanomedicine in tumor sites also has its limitations, as abnormal tumor vasculature, dense stroma structure and altered tumor microenvironment (TME) may result in limited intratumor distribution and therapeutic failure. However, TME-responsive nanomedicine has exhibited immense potential for efficient, safe and precise delivery of therapeutics utilizing stimuli specific to the TME. This review discusses the mechanistic aspects of various TME-responsive biopolymers and their application in developing various types of TME-responsive nanomedicine.
纳米医学通过提高药物的溶解性、渗透性和靶向性，为癌症治疗开辟了新途径。尽管纳米医学在许多方面优于传统疗法，但它可能会表现出非靶向药物分布，从而伤害非目标区域。纳米医学在肿瘤部位的增强渗透和保留效应也有其局限性，因为异常的肿瘤血管、密集的基质结构和改变的肿瘤微环境（TME）可能导致肿瘤内分布有限和治疗失败。然而，TME 响应性纳米医学利用 TME 特有的刺激物，表现出高效、安全和精确输送治疗剂的巨大潜力。本文讨论了各种 TME 响应性生物聚合物的机制方面及其在开发各种 TME 响应性纳米医学中的应用。
