Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Drug Metab Rev. 2024 Feb-May;56(2):127-144. doi: 10.1080/03602532.2024.2326415. Epub 2024 Mar 6.
Severe acute respiratory syndrome 2 (SARS-CoV-2) caused the emergence of the COVID-19 pandemic all over the world. Several studies have suggested that antiviral drugs such as favipiravir (FAV), remdesivir (RDV), and lopinavir (LPV) may potentially prevent the spread of the virus in the host cells and person-to-person transmission. Simultaneously with the widespread use of these drugs, their stability and action mechanism studies have also attracted the attention of many researchers. This review focuses on the action mechanism, metabolites and degradation products of these antiviral drugs (FAV, RDV and LPV) and demonstrates various methods for their quantification and discrimination in the different biological samples. Herein, the instrumental methods for analysis of the main form of drugs or their metabolite and degradation products are classified into two types: optical and chromatography methods which the last one in combination with various detectors provides a powerful method for routine and stability analyses. Some representative studies are reported in this review and the details of them are carefully explained. It is hoped that this review will be a good guideline study and provide a better understanding of these drugs from the aspects investigated in this study.
严重急性呼吸系统综合征 2 型（SARS-CoV-2）导致了 COVID-19 大流行在全球范围内的出现。有几项研究表明，抗病毒药物，如法匹拉韦（FAV）、瑞德西韦（RDV）和洛匹那韦（LPV），可能具有预防病毒在宿主细胞中传播和人际传播的潜力。随着这些药物的广泛使用，它们的稳定性和作用机制研究也引起了许多研究人员的关注。本综述重点介绍了这些抗病毒药物（FAV、RDV 和 LPV）的作用机制、代谢物和降解产物，展示了在不同生物样本中对它们进行定量和鉴别分析的各种方法。在此，用于分析药物主要形式或其代谢物和降解产物的仪器分析方法分为两类：光学方法和色谱方法，后一种方法与各种检测器结合使用，为常规和稳定性分析提供了一种强大的方法。本综述报道了一些有代表性的研究，并对其细节进行了详细解释。希望本综述将成为一个很好的指导研究，并从本研究中考察的方面提供对这些药物的更好理解。
