Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, 77555, United States.
Curr Top Med Chem. 2024;24(10):843-849. doi: 10.2174/0115680266300245240223070242.
Fluorine continues to show its potential applications in drug discovery and development, as reflected by twelve drugs being fluorinated out of the fifty-five approved by the FDA in 2023. This concise review highlights the discovery of each of these fluorine-containing drugs in the past year, including its brand name, date of approval, composition, sponsors, indication, and mechanism of action. The relevant future trend is also briefly discussed.
氟在药物发现和开发中的应用潜力持续显现，在 2023 年美国食品药品监督管理局（FDA）批准的 55 种药物中，有 12 种是经过氟化的。本文简要回顾了过去一年中每一种含氟药物的发现过程，包括其商品名、批准日期、成分、赞助商、适应证和作用机制，并对相关的未来趋势进行了简要讨论。
