Department of Nuclear Medicine, Hacettepe University Medical Center, Ankara, Türkiye.
Department of Nuclear Medicine, Hacettepe University Medical Center, Ankara, Türkiye -
Q J Nucl Med Mol Imaging. 2024 Mar;68(1):32-39. doi: 10.23736/S1824-4785.24.03551-9. Epub 2024 Mar 6.
Differentiated thyroid cancers (DTC) is a rare cancer in children and adolescents, having features of different clinical presentation, biological behavior, and treatment from adult population. Most of the patient management guidelines are based on literature on adult population and the literature on children and adolescents still limited. There are still unsettled issues regarding both patient management and the therapy. However, the current approach for treatment of DTC includes thyroidectomy, lymph node dissection in patients with nodal metastases and possible use of Iodine-131 radiotherapy. The incidence of DTC is low in pediatric population, and the characteristics of the disease vary among different age groups within this population. Therefore, the literature depends on small cohorts and heterogeneous retrospective studies. This paper aims to review the current literature and give an overview to the approach in the management of DTC in pediatric population. DTC in pediatric population, has an aggressive nature, however the patient's overall survival is excellent. A multidisciplinary approach in the management of pediatric DTC patients would yield fewer side effects and a better life quality.
分化型甲状腺癌（DTC）在儿童和青少年中较为罕见，其临床表现、生物学行为和治疗方法与成人不同。大多数患者管理指南都是基于成人的文献，而关于儿童和青少年的文献仍然有限。在患者管理和治疗方面仍存在一些悬而未决的问题。然而，目前 DTC 的治疗方法包括甲状腺切除术、有淋巴结转移的患者淋巴结清扫术以及可能使用碘-131 放疗。DTC 在儿科人群中的发病率较低，且疾病特征在该人群的不同年龄段之间存在差异。因此，文献主要依赖于小队列和异质性回顾性研究。本文旨在综述目前的文献，并概述儿科人群中 DTC 的治疗方法。儿童和青少年的 DTC 具有侵袭性，但患者的总体生存率很高。对儿科 DTC 患者进行多学科治疗可以减少副作用并提高生活质量。
